Intrastromal injection of bevacizumab in patients with corneal neovascularization

被引：16

作者：

Cabreira Vieira, Ana Carolina ^{[1
]}

Hoefling-Lima, Ana Luisa ^{[1
]}

Gomes, Jose Alvaro P. ^{[1
]}

de Freitas, Denise ^{[1
]}

Farah, Michel Eid ^{[1
]}

Belfort, Rubens, Jr. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo UNIFESP, Vis Inst, Dept Ophthalmol, Sao Paulo, Brazil

来源：

ARQUIVOS BRASILEIROS DE OFTALMOLOGIA | 2012年 / 75卷 / 04期

关键词：

Corneal stroma/drug effects; Corneal neovascularization/drug therapy; Injections; intraocular; Antibodies; monoclonal/administration; dosage; INTRAVITREAL BEVACIZUMAB; ANGIOGENESIS; LYMPHANGIOGENESIS; SUBCONJUNCTIVAL; AVASTIN;

D O I：

10.1590/S0004-27492012000400012

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. Anti-VEGF agents have been shown to be effective in slowing the growth of corneal neovessels. Bevacizumab, an anti-VEGF agent, has been successfully used in the treatment of corneal neovascularization. In this paper, we report a series of patients who underwent intracorneal bevacizumab injections to treat corneal vascularization.

引用

页码：277 / 279

页数：3

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