Cell biology of infection by Legionella pneumophila

被引：58
作者：
Xu, Li [1 ]
Luo, Zhao-Qing [1 ]
机构：
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
来源：
MICROBES AND INFECTION | 2013年 / 15卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Intracellular pathogens; Vesicle trafficking; Type IV secretion; Effectors; Host function subversion; NUCLEOTIDE EXCHANGE FACTOR; EFFECTOR PROTEIN DRRA; E3 UBIQUITIN LIGASE; RAB GTPASE FUNCTION; ENDOPLASMIC-RETICULUM; LEGIONNAIRES-DISEASE; VIRULENCE SYSTEM; PLASMA-MEMBRANE; GENE DELETION; HOST;
D O I：
10.1016/j.micinf.2012.11.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Professional phagocytes digest internalized microorganisms by actively delivering them into the phagolysosomal compartment. Intravacuolar bacterial pathogens have evolved a variety of effective strategies to bypass the default pathway of phagosomal maturation to create a niche permissive for their survival and propagation. Here we discuss recent progress in our understanding of the sophisticated mechanisms used by Legionella pneumophila to survive in phagocytes. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：157 / 167
页数：11
相关论文
共 111 条
[1]   Incomplete activation of macrophage a poptosis during intracellular replication of Legionella pneumophila [J].
Abu-Zant, A ;
Santic, M ;
Molmeret, M ;
Jones, S ;
Helbig, J ;
Abu Kwaik, Y .
INFECTION AND IMMUNITY, 2005, 73 (09) :5339-5349
[2]   Anti-apoptotic signalling by the Dot/Icm secretion system of L-pneumophila [J].
Abu-Zant, Alaeddin ;
Jones, Snake ;
Asare, Rexford ;
Suttles, Jill ;
Price, Christopher ;
Graham, James ;
Abu Kwaik, Yousef .
CELLULAR MICROBIOLOGY, 2007, 9 (01) :246-264
[3]   A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa [J].
Al-Khodor, Souhaila ;
Price, Christopher T. ;
Habyarimana, Fabien ;
Kalia, Awdhesh ;
Abu Kwaik, Yousef .
MOLECULAR MICROBIOLOGY, 2008, 70 (04) :908-923
[4]   The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates [J].
Altman, Efrat ;
Segal, Gil .
JOURNAL OF BACTERIOLOGY, 2008, 190 (06) :1985-1996
[5]   The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site [J].
Amor, JC ;
Swails, J ;
Zhu, XJ ;
Roy, CR ;
Nagai, H ;
Ingmundson, A ;
Cheng, XD ;
Kahn, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (02) :1392-1400
[6]   The Legionella pneumophila Effector DrrA Is Sufficient to Stimulate SNARE-Dependent Membrane Fusion [J].
Arasaki, Kohei ;
Toomre, Derek K. ;
Roy, Craig R. .
CELL HOST & MICROBE, 2012, 11 (01) :46-57
[7]   Legionella pneumophila Promotes Functional Interactions between Plasma Membrane Syntaxins and Sec22b [J].
Arasaki, Kohei ;
Roy, Craig R. .
TRAFFIC, 2010, 11 (05) :587-600
[8]   Host-pathogen interactions Cell death and infection: A double-edged sword for host and pathogen survival [J].
Ashida, Hiroshi ;
Mimuro, Hitomi ;
Ogawa, Michinaga ;
Kobayashi, Taira ;
Sanada, Takahito ;
Kim, Minsoo ;
Sasakawa, Chihiro .
JOURNAL OF CELL BIOLOGY, 2011, 195 (06) :931-942
[9]   Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family [J].
Banga, Simran ;
Gao, Ping ;
Shen, Xihui ;
Fiscus, Valena ;
Zong, Wei-Xing ;
Chen, Lingling ;
Luo, Zhao-Qing .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5121-5126
[10]   Temporal resolution of two-tracked NF-κB activation by Legionella pneumophila [J].
Bartfeld, Sina ;
Engels, Cecilia ;
Bauer, Bianca ;
Aurass, Philipp ;
Flieger, Antje ;
Brueggemann, Holger ;
Meyer, Thomas F. .
CELLULAR MICROBIOLOGY, 2009, 11 (11) :1638-1651
12345678910