Isolation and inhibitory activity against ERK Phosphorylation of hydroxyanthraquinones from rhubarb

被引：65

作者：

Zhou, X ^{[1
]}

Song, B ^{[1
]}

Jin, LH ^{[1
]}

Hu, DY ^{[1
]}

Diao, CL ^{[1
]}

Xu, GF ^{[1
]}

Zou, ZH ^{[1
]}

Yang, S ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 03期

关键词：

hydroxyanthraquinones; antitumor bioactivity; ERK phosphorylation;

D O I：

10.1016/j.bmcl.2005.10.047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five hydroxyanthraquinone compounds were purified from Chinese medicinal herb rhubarb by microwave-assisted extraction and silica gel column isolation. Their structures were identified by spectroscopic analysis. One of them, emodin, was found to block the ERK phosphorylation of PC3 cells at 20 mu M. And two other compounds had potent proliferation inhibitory activity on A431 and PC3 cells at 20 mu M. Furthermore, crude extracts revealed an antifungal activity stronger than that of purified compounds against several plant pathogens tested. Together, our study suggests that these compounds are biologically active and may lead to development of anticancer medicine. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：563 / 568

页数：6

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