Heat Shock Factor (HSF): The Promoter of Chaperone Genes. A Mini Review

被引：1
作者：
Quel, Natalia Galdi
Ramos, Carlos H. I.
机构：
[1] Univ Campinas UNICAMP, Inst Chem, Campinas, SP, Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Campinas, SP, Brazil
来源：
CURRENT PROTEOMICS | 2019年 / 16卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Heat shock protein; homeostasis; catalysis; molecular chaperones; protein folding and misfolding; heat shock factor; MOLECULAR CHAPERONES; TRANSCRIPTION FACTOR; CAENORHABDITIS-ELEGANS; ACTIVATION DOMAIN; STRESS-RESPONSE; AMYLOID STATE; FACTOR-I; PROTEIN; HSP70; BINDING;
D O I：
10.2174/1570164615666180713095309
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein homeostasis, or proteostasis, is required for proper cell function and thus must be under tight maintenance in all circumstances. In crowded cell conditions, protein folding is sometimes unfavorable, and this condition is worsened during stress situations. Cells cope with such stress through the use of a Protein Quality Control system, which uses molecular chaperones and heat shock proteins as its major players. This system aids with folding, avoiding misfolding and/or reversing aggregation. A pivotal regulator of the response to heat stress is Heat Shock Factor, which is recruited to the promoters of the chaperone genes, inducting their expression. This mini review aims to cover our general knowledge on the structure and function of this factor.
引用
收藏
页码：22 / 30
页数：9
相关论文
共 50 条
  • [41] Effects of heat stress on yeast heat shock factor-promoter binding in vivo
    Ning Li
    Zhang, Le-Min
    Zhang, Ke-Qin
    Deng, Jing-Shi
    Praendl, Ralf
    Schoeffl, Fritz
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2006, 38 (05) : 356 - 362
  • [42] Analysis of in vivo binding of yeast heat shock factor to promoter DNA
    Liu, K. H.
    Zhang, L. M.
    Ding, X. W.
    Deng, B. W.
    Chen, W. Q.
    AFRICAN JOURNAL OF BIOTECHNOLOGY, 2008, 7 (08): : 1069 - 1071
  • [43] Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9
    Rye, Carl S.
    Chessum, Nicola E. A.
    Lamont, Scott
    Pike, Kurt G.
    Faulder, Paul
    Demeritt, Julie
    Kemmitt, Paul
    Tucker, Julie
    Zani, Lorenzo
    Cheeseman, Matthew D.
    Isaac, Rosie
    Goodwin, Louise
    Boros, Joanna
    Raynaud, Florence
    Hayes, Angela
    Henley, Alan T.
    de Billy, Emmanuel
    Lynch, Christopher J.
    Sharp, Swee Y.
    Poele, Robert Te
    O'Fee, Lisa
    Foote, Kevin M.
    Green, Stephen
    Workman, Paul
    Jones, Keith
    MEDCHEMCOMM, 2016, 7 (08) : 1580 - 1586
  • [44] Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB
    Franks, Hunter
    Wang, Ruishan
    Li, Mingqi
    Wang, Bin
    Wildmann, Ashton
    Ortyl, Tyler
    O'Brien, Shannon
    Young, Deborah
    Liao, Francesca-Fang
    Sakata, Kazuko
    JOURNAL OF NEUROCHEMISTRY, 2023, 165 (02) : 131 - 148
  • [45] Distinct, gene-specific effect of heat shock on heat shock factor-1 and gene expression of CXC chemokine genes
    Maity, Tapan K.
    Henry, Michael M.
    Tulapurkar, Mohan E.
    Shah, Nirav G.
    Hasday, Jeffrey D.
    Singh, Ishwar S.
    CYTOKINE, 2011, 54 (01) : 61 - 67
  • [46] Evolution and co-evolution: insights into the divergence of plant heat shock factor genes
    Parakkunnel, Ramya
    Naik, K. Bhojaraja
    Susmita, C.
    Girimalla, Vanishree
    Bhaskar, K. Udaya
    Sripathy, K., V
    Shantharaja, C. S.
    Aravindan, S.
    Kumar, Sanjay
    Lakhanpaul, Suman
    Bhat, K., V
    PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS, 2022, 28 (05) : 1029 - 1047
  • [47] Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response
    Xu, Meng
    Lin, Ling
    Ram, Babul Moni
    Shriwas, Omprakash
    Chuang, Kun-Han
    Dai, Siyuan
    Su, Kuo-Hui
    Tang, Zijian
    Dai, Chengkai
    CELL REPORTS, 2023, 42 (06):
  • [48] THE HUMAN HEAT-SHOCK PROTEIN HSP70 INTERACTS WITH HSF, THE TRANSCRIPTION FACTOR THAT REGULATES HEAT-SHOCK GENE-EXPRESSION
    ABRAVAYA, K
    MYERS, MP
    MURPHY, SP
    MORIMOTO, RI
    GENES & DEVELOPMENT, 1992, 6 (07) : 1153 - 1164
  • [49] Cloning and in silico characterization of Heat shock factor (Hsf) from Wheat (Triticum aestivum L.)
    Kavita, Dubey
    Suneha, Goswami
    Narendra, Kumar
    Ranjeet, Kumar R.
    Kumar, Niraj Ravi Ranjan
    Khushbu, Singh
    Pooja, Verma
    Prakash, Singh Jyoti
    RESEARCH JOURNAL OF BIOTECHNOLOGY, 2019, 14 (07): : 74 - 80
  • [50] Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals
    Nicholls, Susan
    Leach, Michelle D.
    Priest, Claire L.
    Brown, Alistair J. P.
    MOLECULAR MICROBIOLOGY, 2009, 74 (04) : 844 - 861
12345