Two mononuclear nickel(II) complexes, [Ni(MMP)(NCS)] (1) and [Ni(PMP)(NCS)] (2), where MMP = 5-methoxy-2-[(2-morpholin-4-ylethylimino)methyl]phenolate, PMP = 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenolate, were prepared and structurally characterized by X-ray diffraction. The Ni atom in each complex is four-coordinated by three donor atoms of the Schiff base ligand, and by one thiocyanate N atom, forming a square planar coordination. The urease inhibitory activity of the complexes was evaluated.