Impaired hippocampal synaptic function in secretin deficient mice

被引：27
|
作者：
Yamagata, T. [2 ]
Urano, H. [1 ]
Weeber, E. J. [3 ]
Nelson, D. L. [4 ]
Nishijima, I. [1 ]
机构：
[1] Ohio State Univ, Dept Pediat, Nationwide Childrens Hosp, Ctr Mol & Human Genet,Res Inst, Columbus, OH 43205 USA
[2] Jichi Med Univ, Dept Pediat, Shimotsuke, Tochigi, Japan
[3] Univ S Florida, Dept Mol Pharmacol & Physiol, Tampa, FL 33612 USA
[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
来源：
NEUROSCIENCE | 2008年 / 154卷 / 04期
关键词：
peptide hormone; knock-out mice; hippocampus; synapse; autism; beta-galactosidase;
D O I：
10.1016/j.neuroscience.2008.04.037
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Secretin is a gut peptide hormone that is also expressed in the CNS. To explore the potential neuroactive role of secretin in the brain, we have generated secretin deficient mice. Secretin deficient mice demonstrated impairment in synaptic plasticity (significant reduction in long term potentiation (LTP) induction and LTP maintenance) in the CA1 area of the hippocampus. Using a beta-galactosidase (lacZ) reporter in the targeted allele and secretin antibody staining, we have detected secretin gene expression in the hippocampus, cerebellum, and the brain stem in adult mouse brain. In the hippocampus, secretin was expressed in the dentate gyrus, the hilus, and the molecular layer. These findings suggest that secretin is involved in synaptic function in the adult brain. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1417 / 1422
页数：6
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