Palladium-Catalyzed Oxidative Arylation of Tertiary Benzamides: Para-Selectivity of Monosuhstituted Arenes

被引：42

作者：

Yang, Ze ^{[1
]}

Qiu, Fang-Cheng ^{[1
]}

Gao, Juan ^{[1
]}

Li, Zeng-Wen ^{[1
]}

Guan, Bing-Tao ^{[1
,2
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, State Key Lab & Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 17期

关键词：

C-H ACTIVATION; ARYL BOND FORMATION; COUPLING REACTIONS; FUNCTIONALIZATION; ALKENYLATION; RHODIUM(III); OLEFINATION; C(SP(2))-H; ANILIDES; ALKYNES;

D O I：

10.1021/acs.orglett.5b02135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient protocol for the high para-selective arylation of monosubstituted arenes with tertiary benzamides has been developed via palladium-catalyzed oxidative coupling reactions. Due to the mild conditions and the easy availability of substrates and oxidant, this method could potentially provide a practical approach for the synthesis of para-substituted biaryl compounds.

引用

页码：4316 / 4319

页数：4

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