Palladium-Catalyzed Oxidative Arylation of Tertiary Benzamides: Para-Selectivity of Monosuhstituted Arenes

被引：42
作者：
Yang, Ze [1 ]
Qiu, Fang-Cheng [1 ]
Gao, Juan [1 ]
Li, Zeng-Wen [1 ]
Guan, Bing-Tao [1 ,2 ]
机构：
[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, State Key Lab & Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 17期
关键词：
C-H ACTIVATION; ARYL BOND FORMATION; COUPLING REACTIONS; FUNCTIONALIZATION; ALKENYLATION; RHODIUM(III); OLEFINATION; C(SP(2))-H; ANILIDES; ALKYNES;
D O I：
10.1021/acs.orglett.5b02135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient protocol for the high para-selective arylation of monosubstituted arenes with tertiary benzamides has been developed via palladium-catalyzed oxidative coupling reactions. Due to the mild conditions and the easy availability of substrates and oxidant, this method could potentially provide a practical approach for the synthesis of para-substituted biaryl compounds.
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收藏
页码：4316 / 4319
页数：4
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