Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair

被引：7

作者：

Wang, Qing ^{[1
]}

Yang, Xiaolei ^{[2
]}

Ren, Ming ^{[2
]}

Hu, Yulin ^{[3
]}

Chen, Qiang ^{[2
]}

Xing, Lei ^{[2
]}

Meng, Chunyang ^{[2
]}

Liu, Tiemei ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin Province, Peoples R China

[2] Jilin Univ, Sch Publ Hlth, Dept Toxicol, Changchun 130021, Jilin Province, Peoples R China

[3] Jilin Univ, Hosp 1, Dept Liver Gall & Pancreas, Changchun 130021, Jilin Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 15期

关键词：

chitosan; collagen I; gelatin; biomaterials; biocompatibility; nerve repair; neural regeneration; GELATIN;

D O I：

10.3969/j.issn.1673-5374.2012.15.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by Co-60 irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.

引用

页码：1179 / 1184

页数：6

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