Organocatalyzed Aerobic Oxidation of Aldehydes to Acids

被引：57

作者：

Dai, Peng-Fei ^{[1
]}

Qu, Jian-Ping ^{[2
]}

Kang, Yan-Biao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 05期

基金：

中国国家自然科学基金;

关键词：

TERT-BUTYL NITRITE; CARBOXYLIC-ACIDS; MOLECULAR-OXYGEN; PRIMARY ALCOHOLS; METAL-FREE; CLEAVAGE;

D O I：

10.1021/acs.orglett.9b00101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example organocatalyzed aerobic oxidation of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is developed. As low as 5 mol % N-hydroxyphthalimide was used as the organocatalyst, and molecular O-2 was used as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved. A wide range of carboxylic acids bearing diverse functional groups were obtained from aldehydes, even from alcohols, in high yields.

引用

页码：1393 / 1396

页数：4