The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans

OBJECTIVE: Assessment of the effects of 2 weeks of daily administration of HCA on energy intake and satiety in overweight men and women. DESIGN: A 6-week randomized placebo-controlled single-blinded cross-over trial, Subjects consumed three times daily for 2 weeks 100 ml tomato juice (placebo) and, separated by a 2 week wash-out period, 100 ml tomato juice with 300 mg HCA. SUBJECTS: Twelve males and 12 females (body mass index 27.5 +/- 2.0 kg/m(2); age 37 +/- 10 y). MEASUREMENTS: After 2 weeks, 24 h energy intake (EI), appetite profile, hedonics, mood and possible change in dietary restraint were assessed in the laboratory restaurant. Prevention of degradation and bio-availability was documented. RESULTS: Twenty-four-hour El was decreased by 15-30% (P < 0.05) with HCA treatment compared to placebo, without changes in the appetite profile, dietary restraint, mood, taste perception and hedonics, while body weight tended to decrease (P = 0.1). CONCLUSION: HCA treatment reduced 24 h El in humans while satiety was sustained.