IL-21-Producing Th Cells in Immunity and Autoimmunity

被引：83

作者：

Liu, Sue M.

King, Cecile

机构：

[1] St Vincents Hosp, Garvan Inst Med Res, Immunol Dis Program, Darlinghurst, NSW 2010, Australia

[2] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2013年 / 191卷 / 07期

关键词：

FOLLICULAR-HELPER-CELLS; TGF-BETA; B-CELL; CRITICAL CYTOKINE; CUTTING EDGE; T(H)17 CELLS; C-MAF; IL-21; DIFFERENTIATION; INTERLEUKIN-21;

D O I：

10.4049/jimmunol.1301454

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-21 is a member of the common g-chain signaling family of cytokines. Analyses of the behavior of immune cells in response to IL-21 in vitro and studies of mice deficient in IL-21 or its receptor indicate that IL-21 has a role in lymphocyte activation, proliferation, differentiation, and survival. IL-21-producing CD4(+) Th cells constitute a broad array of helper subtypes including T follicular helper cells and Th17 cells. Both autocrine and paracrine utilization of IL-21 contributes to the overall signal transduction pathways of the Ag receptor to influence the growth and survival of lymphocytes. The redundancy that IL-21 exhibits in lymphoid organs during immune responses is in stark contrast to the evidence that pharmacological neutralization of this cytokine can halt inflammation in nonlymphoid organs where IL-21 becomes the dominant voice.

引用

页码：3501 / 3506

页数：6

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