IL-21-Producing Th Cells in Immunity and Autoimmunity

被引：83

作者：

Liu, Sue M.

King, Cecile

机构：

[1] St Vincents Hosp, Garvan Inst Med Res, Immunol Dis Program, Darlinghurst, NSW 2010, Australia

[2] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2013年 / 191卷 / 07期

关键词：

FOLLICULAR-HELPER-CELLS; TGF-BETA; B-CELL; CRITICAL CYTOKINE; CUTTING EDGE; T(H)17 CELLS; C-MAF; IL-21; DIFFERENTIATION; INTERLEUKIN-21;

D O I：

10.4049/jimmunol.1301454

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-21 is a member of the common g-chain signaling family of cytokines. Analyses of the behavior of immune cells in response to IL-21 in vitro and studies of mice deficient in IL-21 or its receptor indicate that IL-21 has a role in lymphocyte activation, proliferation, differentiation, and survival. IL-21-producing CD4(+) Th cells constitute a broad array of helper subtypes including T follicular helper cells and Th17 cells. Both autocrine and paracrine utilization of IL-21 contributes to the overall signal transduction pathways of the Ag receptor to influence the growth and survival of lymphocytes. The redundancy that IL-21 exhibits in lymphoid organs during immune responses is in stark contrast to the evidence that pharmacological neutralization of this cytokine can halt inflammation in nonlymphoid organs where IL-21 becomes the dominant voice.

引用

页码：3501 / 3506

页数：6

共 91 条

[11] T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells [J].

Chtanova, T ;

Tangye, SG ;

Newton, R ;

Frank, N ;

Hodge, MR ;

Rolph, MS ;

Mackay, CR .

JOURNAL OF IMMUNOLOGY, 2004, 173 (01) :68-78

[12] Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions [J].

Chung, Yeonseok ;

Tanaka, Shinya ;

Chu, Fuliang ;

Nurieva, Roza I. ;

Martinez, Gustavo J. ;

Rawal, Seema ;

Wang, Yi-Hong ;

Lim, Hoyong ;

Reynolds, Joseph M. ;

Zhou, Xiao-hui ;

Fan, Hui-min ;

Liu, Zhong-ming ;

Neelapu, Sattva S. ;

Dong, Chen .

NATURE MEDICINE, 2011, 17 (08) :983-U102

[13] Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis [J].

Coquet, Jonathan M. ;

Chakravarti, Sumone ;

Smyth, Mark J. ;

Godfrey, Dale I. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (11) :7097-7101

[14] Follicular Helper CD4 T Cells (TFH) [J].

Crotty, Shane .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :621-663

[15] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain [J].

Cua, DJ ;

Sherlock, J ;

Chen, Y ;

Murphy, CA ;

Joyce, B ;

Seymour, B ;

Lucian, L ;

To, W ;

Kwan, S ;

Churakova, T ;

Zurawski, S ;

Wiekowski, M ;

Lira, SA ;

Gorman, D ;

Kastelein, RA ;

Sedgwick, JD .

NATURE, 2003, 421 (6924) :744-748

[16]

Cyster JG, 2000, IMMUNOL REV, V176, P181

[17] IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells [J].

Dardalhon, Valerie ;

Awasthi, Amit ;

Kwon, Hyoung ;

Galileos, George ;

Gao, Wenda ;

Sobel, Raymond A. ;

Mitsdoerffer, Meike ;

Strom, Terry B. ;

Elyaman, Wassim ;

Ho, I-Cheng ;

Khoury, Samia ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2008, 9 (12) :1347-1355

[18] IL-21 Limits Peripheral Lymphocyte Numbers through T Cell Homeostatic Mechanisms [J].

Datta, Shrimati ;

Sarvetnick, Nora E. .

PLOS ONE, 2008, 3 (09)

[19] Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells [J].

de Beaucoudrey, Ludovic ;

Puel, Anne ;

Filipe-Santos, Orchidee ;

Cobat, Aurelie ;

Ghandil, Pegah ;

Chrabieh, Maya ;

Feinberg, Jacqueline ;

von Bernuth, Horst ;

Samarina, Arina ;

Janniere, Lucile ;

Fieschi, Claire ;

Stephan, Jean-Louis ;

Boileau, Catherine ;

Lyonnet, Stanislas ;

Jondeau, Guillaume ;

Cormier-Daire, Valerie ;

Le Merrer, Martine ;

Hoarau, Cyrille ;

Lebranchu, Yvon ;

Lortholary, Olivier ;

Chandesris, Marie-Olivia ;

Tron, Francois ;

Gambineri, Eleonora ;

Bianchi, Lucia ;

Rodriguez-Gallego, Carlos ;

Zitnik, Simona E. ;

Vasconcelos, Julia ;

Guedes, Margarida ;

Vitor, Artur Bonito ;

Marodi, Laszlo ;

Chapel, Helen ;

Reid, Brenda ;

Roifman, Chaim ;

Nadal, David ;

Reichenbach, Janine ;

Caragol, Isabel ;

Garty, Ben-Zion ;

Dogu, Figen ;

Camcioglu, Yildiz ;

Gulle, Sanyie ;

Sanal, Ozden ;

Fischer, Alain ;

Abel, Laurent ;

Stockinger, Birgitta ;

Picard, Capucine ;

Casanova, Jean-Laurent .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1543-1550

[20] Interleukin-21 triggers effector cell responses in the gut [J].

De Nitto, Daniela ;

Sarra, Massimiliano ;

Pallone, Francesco ;

Monteleone, Giovanni .

WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (29) :3638-3641

← 1 2 3 4 5 6 7 8 9 10 →