Bisphosphonate-related osteonecrosis of the jaw in non-malignant bone disease

被引：4
作者：
Wong, Peter K. [1 ,2 ]
Borromeo, Gelsomina L. [3 ]
Wark, John D. [4 ,5 ]
机构：
[1] Midnorth Coast Arthrit Clin, Coffs Harbour, NSW 2450, Australia
[2] Univ New S Wales, Rural Clin Sch, Fac Med, Kensington, NSW 2033, Australia
[3] Univ Melbourne, Melbourne Dent Sch, Melbourne, Vic, Australia
[4] Univ Melbourne, Dept Med, Melbourne, Vic 3052, Australia
[5] Royal Melbourne Hosp, Melbourne, Vic, Australia
来源：
RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 09期
关键词：
Bisphosphonate; Osteonecrosis; Jaw; Non-malignant; Bone; OF-THE-LITERATURE; ZOLEDRONIC-ACID; RISK-FACTORS; MULTIPLE-MYELOMA; AMERICAN ASSOCIATION; ORAL BISPHOSPHONATES; POSTMENOPAUSAL WOMEN; PREVENTIVE MEASURES; AVASCULAR NECROSIS; CLINICAL-FEATURES;
D O I：
10.1007/s00296-013-2771-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with delayed dental healing and even the devastating complication of osteonecrosis of the jaw (ONJ). Extensive media attention highlighting this issue has caused much concern among patients and healthcare professionals. This paper seeks to provide treating clinicians with a balanced multi-disciplinary review of the available evidence pertaining to this issue and practical advice regarding prevention and management of ONJ.
引用
收藏
页码：2189 / 2198
页数：10
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