In situ forming parenteral depot systems based on poly(ethylene carbonate): Effect of polymer molecular weight on model protein release

被引：12

作者：

Chu, Dafeng ^{[1
]}

Curdy, Catherine ^{[2
]}

Riebesehl, Bernd ^{[2
]}

Beck-Broichsitter, Moritz ^{[1
]}

Kissel, Thomas ^{[1
]}

机构：

[1] Univ Marburg, Dept Pharmaceut & Biopharm, D-35032 Marburg, Germany

[2] Novartis Pharma AG, Basel, Switzerland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2013年 / 85卷 / 03期

关键词：

In situ forming depots; Surface-eroding polymers; Poly(ethylene carbonate); Drug release; Initial burst; Water swelling; DRUG-DELIVERY SYSTEMS; POLY(TRIMETHYLENE CARBONATE); VIVO; BIODEGRADATION; DEGRADATION; IMPLANTS; BEHAVIOR;

D O I：

10.1016/j.ejpb.2013.05.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this study was to investigate the effect of molecular weight (MW) on the drug release from poly(ethylene carbonate) (PEC) based surface-eroding in situ forming depots (ISFD). In phosphate buffered saline (PBS) pH 7.4, 63.7% of bovine serum albumin BSA was released from high MW PEC of 200 kDa (PEC200) in DMSO (15%, w/w) in 2 days, while during the same time period, the release of BSA from PEC41 samples was only 22.5%. At higher concentrations of PEC41 (25%, w/w), the initial burst was further reduced, and even after 6 days, only 16.3% was released. Compared to depots based on PEC200, there was lower rate of solvent release, slower phase inversion, and a denser surface in PEC41 samples. An expansion in size of PEC41 depots suggested that the polymer barrier of PEC41 impeded the diffusion of solvent out of the samples effectively. In conclusion, the initial burst of protein from ISFD of PEC41 was significantly reduced, which. would be a promising candidate as polymeric carrier. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1245 / 1249

页数：5