H5N1;
HPAI;
South Korea;
Mongolia;
Domestic duck;
Mice;
AVIAN INFLUENZA;
WILD BIRDS;
HONG-KONG;
A VIRUSES;
VIRULENCE;
EVOLUTION;
POULTRY;
D O I:
10.1016/j.vetmic.2013.09.013
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Influenza virus A (H5N1) clade 2.3.2.1 has recently caused widespread outbreaks of disease in domestic poultry and wild birds in Eastern Asia. In the current study, the antigenicity and pathogenicity of three clade 2.3.2.1 viruses (Ck/Kr/Gimje/08, Ws/Mongolia/1/09, and Ws/Mongolia/7/10) were investigated in domestic ducks and mice. The H5N1 influenza viruses in this study were antigenically similar to each other (r-values of 0.35-1.4). The three viruses replicated systemically in all tissues tested in domestic ducks, indicating high pathogenicity. However, the viruses produced different clinical signs and mortality rates: Ck/Kr/Gimje/08 and Ws/Mongolia/1/09 resulted in 100% mortality with severe neurological signs, whereas Ws/Mongolia/7/10 resulted in 50% mortality with relatively mild neurological signs. In mice, infection with Ck/Kr/Gimje/08 and Ws/Mongolia/7/10 resulted in weight loss that peaked at 4 days post-infection (22.3% and 20.8%, respectively), same MLD50 (2.2 Log(10) EID50) and systemic replication. The three viruses had K deletion at the 2 position of the HA1-connecting peptide (PQRERRRK-R), which is associated with increased virulence in domestic ducks and harbored NA stalk deletion, NS1 deletion and mutation of P42S in NS1, and full length (90aa) in PB1-F2, which confer increased virulence in mice. Our study shows that clade 2.3.2.1 viruses from Korea and Mongolia are antigenically similar and highly pathogenic in both domestic ducks and mice. Moreover, we provide molecular determinants of the clade 2.3.2.1 viruses associated with the pathogenicity in domestic ducks and mice, respectively. (C) 2013 Elsevier B.V. All rights reserved.
机构:
Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USAUniv Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Brown, Justin D.
;
Stallknecht, David E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Stallknecht, David E.
;
Beck, Joan R.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Beck, Joan R.
;
Suarez, David L.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Suarez, David L.
;
Swayne, David E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Fan, Shufang
;
Gao, Yuwei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Gao, Yuwei
;
Shinya, Kyoko
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Int Ctr Med Res & Treatment, Kobe, Hyogo 657, JapanChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Shinya, Kyoko
;
Li, Chris Kafai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX1 2JD, EnglandChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Li, Chris Kafai
;
Li, Yanbing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Li, Yanbing
;
Shi, Jianzhong
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Shi, Jianzhong
;
Jiang, Yongping
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Jiang, Yongping
;
Suo, Yongbing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Suo, Yongbing
;
Tong, Tiegang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Tong, Tiegang
;
Zhong, Gongxun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Zhong, Gongxun
;
Song, Jiasheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Song, Jiasheng
;
Zhang, Ying
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Zhang, Ying
;
Tian, Guobin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Tian, Guobin
;
Guan, Yuntao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Guan, Yuntao
;
Xu, Xiao-Ning
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX1 2JD, EnglandChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Xu, Xiao-Ning
;
Bu, Zhigao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Bu, Zhigao
;
Kawaoka, Yoshihiro
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Int Ctr Med Res & Treatment, Kobe, Hyogo 657, Japan
Univ Tokyo, Div Virol, Dept Microbiol & Immunol, Tokyo, Japan
Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan
Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USAChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Kawaoka, Yoshihiro
;
Chen, Hualan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
机构:
Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Jackson, David
;
Hossain, Md. Jaber
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Hossain, Md. Jaber
;
Hickman, Danielle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Hickman, Danielle
;
Perez, Daniel R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Perez, Daniel R.
;
Lamb, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
机构:
Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USAUniv Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Brown, Justin D.
;
Stallknecht, David E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Stallknecht, David E.
;
Beck, Joan R.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Beck, Joan R.
;
Suarez, David L.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
Suarez, David L.
;
Swayne, David E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA 30602 USA
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Fan, Shufang
;
Gao, Yuwei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Gao, Yuwei
;
Shinya, Kyoko
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Int Ctr Med Res & Treatment, Kobe, Hyogo 657, JapanChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Shinya, Kyoko
;
Li, Chris Kafai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX1 2JD, EnglandChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Li, Chris Kafai
;
Li, Yanbing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Li, Yanbing
;
Shi, Jianzhong
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Shi, Jianzhong
;
Jiang, Yongping
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Jiang, Yongping
;
Suo, Yongbing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Suo, Yongbing
;
Tong, Tiegang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Tong, Tiegang
;
Zhong, Gongxun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Zhong, Gongxun
;
Song, Jiasheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Song, Jiasheng
;
Zhang, Ying
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Zhang, Ying
;
Tian, Guobin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Tian, Guobin
;
Guan, Yuntao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Guan, Yuntao
;
Xu, Xiao-Ning
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX1 2JD, EnglandChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Xu, Xiao-Ning
;
Bu, Zhigao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Bu, Zhigao
;
Kawaoka, Yoshihiro
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Int Ctr Med Res & Treatment, Kobe, Hyogo 657, Japan
Univ Tokyo, Div Virol, Dept Microbiol & Immunol, Tokyo, Japan
Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan
Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USAChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Kawaoka, Yoshihiro
;
Chen, Hualan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
Chinese Acad Agr Sci, Natl Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R ChinaChinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China
机构:
Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Jackson, David
;
Hossain, Md. Jaber
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Hossain, Md. Jaber
;
Hickman, Danielle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Hickman, Danielle
;
Perez, Daniel R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Vet Med, College Pk, MD 20742 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Perez, Daniel R.
;
Lamb, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USANorthwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA