Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of Tripterygium wilfordii

被引：26

作者：

Chen, Fang-You

Li, Chuang-Jun

Ma, Jie

Zhou, Jian

Li, Li

Zhang, Zhao

Chen, Nai-Hong

Zhang, Dong-Ming ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 02期

关键词：

ABIETANE DITERPENOIDS; PYRIDINE ALKALOIDS; ROOTS; CONSTITUENTS;

D O I：

10.1021/acs.jnatprod.7b00615

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known sesquiterpenoid alkaloid, were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques and the ECD method were used for the structure elucidation of the compounds. The structures of compounds 1 and 8 were confirmed by single-crystal X-ray crystallographic analyses. Compounds 8, 9, 11, 12, and 13 increased cell viability of the okadaic acid treated PC12 cells from 60.4 +/- 23.0% to 72.4 +/- 14.1, 71.5 +/- 11.5, 75.7 +/- 15.6, 81.2 +/- 13.1, and 86.2 +/- 25.5% at 10 mu M, respectively.

引用

页码：270 / 278

页数：9

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