Synergistic effects of anti-MRSA herbal extracts combined with antibiotics

被引：24

作者：

Bao, Mei ^{[1
,2
]}

Zhang, Lulu ^{[1
,2
]}

Liu, Bin ^{[2
]}

Li, Li ^{[2
]}

Zhang, Yin ^{[1
,2
]}

Zhao, Heru ^{[1
,2
]}

Jig, Xinyu ^{[2
]}

Chen, Qing ^{[1
,2
]}

Hu, Mingliang ^{[1
,2
]}

Bai, Jingan ^{[2
]}

Pang, Guoming ^{[3
]}

Yi, Jianfeng ^{[1
]}

Tan, Yong ^{[2
]}

Lu, Cheng ^{[2
]}

机构：

[1] Yichun Univ, Key Lab Res Act Ingredients Nat Med Jiangxi Prov, Yichun, Peoples R China

[2] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China

[3] Kaifeng Hosp Tradit Chinese Med, Kaifeng, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2020年 / 15卷 / 13期

关键词：

antibiotic; herbal extract; MRSA; synergistic effect; RESISTANT STAPHYLOCOCCUS-AUREUS; MINIMUM INHIBITORY CONCENTRATION; CHINESE MEDICINAL-PLANTS; BETA-LACTAM ANTIBIOTICS; IN-VITRO ACTIVITY; METHICILLIN-RESISTANT; ANTIMICROBIAL ACTIVITY; QUINOLONE RESISTANCE; EFFLUX PUMPS; FLUOROQUINOLONE RESISTANCE;

D O I：

10.2217/fmb-2020-0001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MRSA is a super drug-resistant bacterium. Developing new drug or therapeutic strategies against MRSA is urgently needed. Increasing evidence has shown that herbal extracts and antibiotics can have synergistic effects against MRSA. This review focuses on commonly used antibiotics combined with herbal extracts against MRSA and the corresponding mechanisms. Through systematic analysis, we found that herbal extracts combined with antibiotics, such as beta-lactams, quinolones, aminoglycosides, tetracyclines and glycopeptides, could greatly enhance the antibacterial effects of the antibiotics, reduce the dosage and toxic side effects, and reverse MRSA resistance. Therefore, we conclude that herbal extracts combined with antibiotics may be a promising strategy to combat MRSA. This review provides a novel idea for overcoming antibiotic resistance.

引用

页码：1265 / 1276

页数：12

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