Nickel-Catalyzed Cycloaddition of 1,3-Dienes with 3-Azetidinones and 3-Oxetanones

被引：60

作者：

Thakur, Ashish ^{[1
]}

Facer, Megan E. ^{[1
]}

Louie, Janis ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期

关键词：

azetidinones; CC activation; cycloaddition; nickel; oxetanones; C-C BOND; ALDEHYDE OXIDATION LEVEL; FORMING TRANSFER HYDROGENATION; STEREOSELECTIVE CONSTRUCTION; COUPLING REACTIONS; OLEFIN INSERTION; RUTHENIUM; ALKYNES; ALCOHOL; DIENES;

D O I：

10.1002/anie.201306869

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A growth and expansion strategy: A Ni/P(p-tol)3-catalyzed cycloaddition of 1,3-dienes with 3-azetidinones and 3-oxetanones produced eight-membered heterocycles with a variety of substituents (see scheme; Boc=tert-butoxycarbonyl). The synthesis of the reduced azocine and oxocine derivatives involved the challenging steps of C(sp2)-C(sp 3) bond activation and C(sp3)-C(sp3) reductive elimination. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12161 / 12165

页数：5

共 119 条

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[Anonymous], 2012, ANGEW CHEM

[2]

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