Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review

被引：88
作者：
Ukon, Yuichiro [1 ]
Makino, Takahiro [1 ]
Kodama, Joe [1 ]
Tsukazaki, Hiroyuki [1 ]
Tateiwa, Daisuke [1 ]
Yoshikawa, Hideki [1 ]
Kaito, Takashi [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Orthoped Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 10期
基金：
日本学术振兴会;
关键词：
osteoporosis; bone metabolism; osteoblast; osteoclast; bisphosphonate; parathyroid hormone; calcitonin; receptor activator of nuclear factor B; sclerostin; stem cell; BONE-MINERAL DENSITY; PARATHYROID-HORMONE; 1-34; MESENCHYMAL STEM-CELLS; RANDOMIZED CONTROLLED-TRIAL; VITAMIN-D SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; ESTROGEN-RECEPTOR-ALPHA; VERTEBRAL FRACTURE RATE; POSTMENOPAUSAL WOMEN; SALMON-CALCITONIN;
D O I：
10.3390/ijms20102557
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators, bisphosphonates, anti-receptor activator of nuclear factor B ligand antibody along with calcium and vitamin D supplementations) and anabolic agents (parathyroid hormone and related peptide analogs, sclerostin inhibitors) have major roles in current treatment regimens and are used alone or in combination based on the pathological condition. Recent advancements in the molecular understanding of bone metabolism and in bioengineering will open the door to future treatment paradigms for osteoporosis, including antibody agents, stem cells, and gene therapies. This review provides an overview of the molecular mechanisms, clinical evidence, and potential adverse effects of drugs that are currently used or under development for the treatment of osteoporosis to aid clinicians in deciding how to select the best treatment option.
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页数：24
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