Dysplastic nevus: Fact and fiction

被引:36
作者
Rosendahl, Cliff O. [1 ]
Grant-Kels, Jane M. [2 ]
Que, Syril Keena T. [2 ]
机构
[1] Univ Queensland, Sch Med, Brisbane, Qld 4072, Australia
[2] Univ Connecticut, Ctr Hlth, Dept Dermatol, Farmington, CT 06032 USA
关键词
B-K mole syndrome; BRAF; common nevus; congenital melanocytic nevus; cyclin-dependent kinase inhibitor 2A (CDKN2A); dysplastic nevus; familial atypical multiple-mole melanoma; melanoma; p16; p53; CONGENITAL MELANOCYTIC NEVI; CUTANEOUS MELANOMA; MALIGNANT-MELANOMA; BENIGN NEVI; ASSOCIATION; MUTATIONS; RISK; OUTCOMES; LESIONS; ATYPIA;
D O I
10.1016/j.jaad.2015.04.029
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The term "dysplastic nevus" (DN) implies that this nevus exists as a distinct and defined entity of potential detriment to its host. We examine the current data, which suggest that this entity exists as histologically and possibly genetically different from common nevus, with some overlapping features. Studies show that a melanoma associated with a nevus is just as likely to arise in a common nevus as in DN. Furthermore, there is no evidence that a histologically defined DN evolves into a melanoma or that the presence of 1 or more DN on an individual patient confers any increased melanoma risk. We suggest that the term "dysplastic nevus" be abandoned so that the focus can shift to confirmed and relevant indicators of melanoma risk, including high nevus counts and large nevus size.
引用
收藏
页码:507 / 512
页数:6
相关论文
共 52 条
  • [1] Histologic Outcomes of Excised Moderate and Severe Dysplastic Nevi
    Abello-Poblete, Maria V.
    Correa-Selm, Lilia M.
    Giambrone, Danielle
    Victor, Frank
    Rao, Babar K.
    [J]. DERMATOLOGIC SURGERY, 2014, 40 (01) : 40 - 45
  • [2] Ackerman AB, 2007, DERMATOPATHOLOGY PRA, V13
  • [3] Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi
    Annessi, G
    Cattaruzza, MS
    Abeni, D
    Baliva, G
    Laurenza, M
    Macchini, V
    Melchi, F
    Ruatti, P
    Puddu, P
    Faraggiana, T
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (01) : 77 - 85
  • [4] [Anonymous], J AM ACAD DERMATOL
  • [5] [Anonymous], 2012, J AM ACAD DERMATOL
  • [6] Grading of atypia in nevi: Correlation with melanoma risk
    Arumi-Uria, M
    McNutt, S
    Finnerty, B
    [J]. MODERN PATHOLOGY, 2003, 16 (08) : 764 - 771
  • [7] HISTOLOGIC FEATURES OF CONGENITAL MELANOCYTIC NEVI IN INFANTS 1 YEAR OF AGE OR YOUNGER
    BARNHILL, RL
    FLEISCHLI, M
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1995, 33 (05) : 780 - 785
  • [8] Batinac T, 2007, COLLEGIUM ANTROPOL, V31, P17
  • [9] Cutaneous melanomas associated with nevi
    Bevona, C
    Goggins, W
    Quinn, T
    Fullerton, J
    Tsao, H
    [J]. ARCHIVES OF DERMATOLOGY, 2003, 139 (12) : 1620 - 1624
  • [10] GENETIC ASPECTS OF MALIGNANT MELANOMA
    CAWLEY, EP
    [J]. AMA ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, 1952, 65 (04): : 440 - 450