CD8+ T cell help is required for efficient induction of EAE in Lewis rats

被引：19

作者：

Camara, Monika ^{[1
]}

Beyersdorf, Niklas ^{[1
]}

Fischer, Henrike J. ^{[2
]}

Herold, Marco J. ^{[3
]}

Ip, Chi Wang ^{[4
]}

van den Brandt, Jens ^{[2
]}

Toyka, Klaus V. ^{[4
]}

Taurog, Joel D. ^{[5
]}

Huenig, Thomas ^{[1
]}

Herrmann, Thomas ^{[1
]}

Reichardt, Holger M. ^{[2
]}

Weishaupt, Andreas ^{[4
]}

Kerkau, Thomas ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Virol & Immunobiol, D-97078 Wurzburg, Germany

[2] Univ Gottingen, Sch Med, Dept Cellular & Mol Immunol, D-37073 Gottingen, Germany

[3] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[4] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany

[5] UT Southwestern Med Ctr, Dallas, TX 75390 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 260卷 / 1-2期

关键词：

Experimental autoimmune encephalomyelitis; Multiple sclerosis; CD8(+) T cell; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; CORTICAL DEMYELINATION; MONOCLONAL-ANTIBODIES; IMMUNE TOLERANCE; ANTIGEN THERAPY; INFLAMMATION;

D O I：

10.1016/j.jneuroim.2013.04.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of CD8(+) T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats, depleted of CD8(+) T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4(+) T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-gamma-producing effector cells. Our results indicate that CD8(+) T cells interact with myelin-specific CD4(+) T cells early in EAE enabling them to differentiate into pathogenic effector cells. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：17 / 27

页数：11

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