One-Pot Three-Component Reaction between 2-Aminopyridines, Aldehydes and Meldrum's Acid in Water: An Efficient Synthesis of β-Amino Acids

被引:4
作者
Adib, Mehdi [1 ]
Fatemi, Solmaz [1 ]
Nosrati, Meisam [1 ]
Bijanzadeh, Hamid Reza [2 ]
机构
[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran
[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
关键词
beta-amino acids; 2-aminopyridines; aldehydes; Meldrum's acid; three-component reactions; synthesis in water;
D O I
10.1055/s-0028-1087279
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel, one-pot, three-component synthesis of beta-amino acids is described. Heating an alkaline aqueous solution of a 2-aminopyridine, an aldehyde and Meldrum's acid afforded beta-amino acids in good to excellent yields.
引用
收藏
页码:3177 / 3179
页数:3
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