One-Pot Three-Component Reaction between 2-Aminopyridines, Aldehydes and Meldrum's Acid in Water: An Efficient Synthesis of β-Amino Acids

被引：4

作者：

Adib, Mehdi ^{[1
]}

Fatemi, Solmaz ^{[1
]}

Nosrati, Meisam ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

机构：

[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2008年 / 20期

关键词：

beta-amino acids; 2-aminopyridines; aldehydes; Meldrum's acid; three-component reactions; synthesis in water;

D O I：

10.1055/s-0028-1087279

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, three-component synthesis of beta-amino acids is described. Heating an alkaline aqueous solution of a 2-aminopyridine, an aldehyde and Meldrum's acid afforded beta-amino acids in good to excellent yields.

引用

页码：3177 / 3179

页数：3

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