Testosterone Administration in Older Men

被引:17
作者
Matsumoto, Alvin M. [1 ,2 ,3 ,4 ]
机构
[1] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA 98108 USA
[2] VA Puget Sound Hlth Care Syst, Clin Res Unit, Seattle, WA 98108 USA
[3] Univ Washington, Sch Med, Div Gerontol & Geriatr Med, Dept Med, Seattle, WA 98195 USA
[4] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA
关键词
Hypogonadism; Aging; Diagnosis; Testosterone; Treatment; SEX-HORMONE LEVELS; SERUM TESTOSTERONE; ANDROGEN DEFICIENCY; HEALTHY-YOUNG; ADULT MEN; PROSTATE; THERAPY; PHARMACOKINETICS; HYPOGONADISM; PREVALENCE;
D O I
10.1016/j.ecl.2013.02.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The only indication for testosterone administration in older men is testosterone replacement therapy for male hypogonadism. Compared with young hypogonadal men, the diagnosis and management of male hypogonadism in older men is more challenging. Both the clinical manifestations of androgen deficiency and low testosterone levels may be caused or modified by comorbid illnesses that occur and medications taken more frequently by older men, resulting in a greater likelihood for overdiagnosis of hypogonadism and subsequent inappropriate use of and inadequate response to testosterone treatment. It is important to use a systematic, holistic approach to the diagnosis and management of older men with hypogonadism.
引用
收藏
页码:271 / +
页数:17
相关论文
共 32 条
[1]   Performance of Total Testosterone Measurement to Predict Free Testosterone for the Biochemical Evaluation of Male Hypogonadism [J].
Anawalt, Bradley D. ;
Hotaling, James M. ;
Walsh, Thomas J. ;
Matsumoto, Alvin M. .
JOURNAL OF UROLOGY, 2012, 187 (04) :1369-1373
[2]   Mortality Results from a Randomized Prostate-Cancer Screening Trial [J].
Andriole, Gerald L. ;
Grubb, Robert L., III ;
Buys, Saundra S. ;
Chia, David ;
Church, Timothy R. ;
Fouad, Mona N. ;
Gelmann, Edward P. ;
Kvale, Paul A. ;
Reding, Douglas J. ;
Weissfeld, Joel L. ;
Yokochi, Lance A. ;
Crawford, E. David ;
O'Brien, Barbara ;
Clapp, Jonathan D. ;
Rathmell, Joshua M. ;
Riley, Thomas L. ;
Hayes, Richard B. ;
Kramer, Barnett S. ;
Izmirlian, Grant ;
Miller, Anthony B. ;
Pinsky, Paul F. ;
Prorok, Philip C. ;
Gohagan, John K. ;
Berg, Christine D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) :1310-1319
[3]   Prevalence and incidence of androgen deficiency in middle-aged and older men: Estimates from the Massachusetts Male Aging Study [J].
Araujo, AB ;
O'Donnell, AB ;
Brambilla, DJ ;
Simpson, WB ;
Longcope, C ;
Matsumoto, AM ;
McKinlay, JB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (12) :5920-5926
[4]   Prevalence of symptomatic androgen deficiency in men [J].
Araujo, Andre B. ;
Esche, Gretchen R. ;
Kupelian, Varant ;
O'Donnell, Amy B. ;
Travison, Thomas G. ;
Williams, Rachel E. ;
Clark, Richard V. ;
McKinlay, John B. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (11) :4241-4247
[5]   Risk Factors Associated With Cardiovascular Events During Testosterone Administration in Older Men With Mobility Limitation [J].
Basaria, Shehzad ;
Davda, Maithili N. ;
Travison, Thomas G. ;
Ulloor, Jagadish ;
Singh, Ravinder ;
Bhasin, Shalender .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013, 68 (02) :153-160
[6]   Adverse Events Associated with Testosterone Administration [J].
Basaria, Shehzad ;
Coviello, Andrea D. ;
Travison, Thomas G. ;
Storer, Thomas W. ;
Farwell, Wildon R. ;
Jette, Alan M. ;
Eder, Richard ;
Tennstedt, Sharon ;
Ulloor, Jagadish ;
Zhang, Anqi ;
Choong, Karen ;
Lakshman, Kishore M. ;
Mazer, Norman A. ;
Miciek, Renee ;
Krasnoff, Joanne ;
Elmi, Ayan ;
Knapp, Philip E. ;
Brooks, Brad ;
Appleman, Erica ;
Aggarwal, Sheetal ;
Bhasin, Geeta ;
Hede-Brierley, Leif ;
Bhatia, Ashmeet ;
Collins, Lauren ;
LeBrasseur, Nathan ;
Fiore, Louis D. ;
Bhasin, Shalender .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (02) :109-122
[7]   Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline [J].
Bhasin, Shalender ;
Cunningham, Glenn R. ;
Hayes, Frances J. ;
Matsumoto, Alvin M. ;
Snyder, Peter J. ;
Swerdloff, Ronald S. ;
Montori, Victor M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (06) :2536-2559
[8]   Testosterone use in men with sexual dysfunction:: A systematic review and meta-analysis of randomized placebo-controlled trials [J].
Bolona, Enrique R. ;
Uraga, Maria V. ;
Haddad, Rudy M. ;
Tracz, Michal J. ;
Sideras, Kostandinos ;
Kennedy, Cassie C. ;
Caples, Sean M. ;
Erwin, Patricia J. ;
Montori, Victor M. .
MAYO CLINIC PROCEEDINGS, 2007, 82 (01) :20-28
[9]   Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men [J].
Brambilla, Donald J. ;
O'Donnell, Amy B. ;
Matsumoto, Alvin M. ;
McKinlay, John B. .
CLINICAL ENDOCRINOLOGY, 2007, 67 (06) :853-862
[10]   The Effect of Diurnal Variation on Clinical Measurement of Serum Testosterone and Other Sex Hormone Levels in Men [J].
Brambilla, Donald J. ;
Matsumoto, Alvin M. ;
Araujo, Andre B. ;
McKinlay, John B. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (03) :907-913