Synthesis and biological activity of the 2-amino-4-(4-iodophenyl)amino-6-methylpyrimidine isosteric analogs

被引：0

作者：

Erkin, A. V. ^{[1
]}

Krutikov, V. I. ^{[1
]}

机构：

[1] Tech Univ, St Petersburg State Inst Technol, St Petersburg 190013, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2013年 / 83卷 / 03期

关键词：

Halogen Atom; Hydrogen Chloride; Mycobacterium Smegmatis; Phosphorus Oxychloride; Aqueous Potassium Hydroxide;

D O I：

10.1134/S1070363213030213

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transformation of the structure of 6-methylisocytosine results in the isosteric analogs of 2-amino-4-(4-iodophenyl)amino-6-methylpyrimidine exhibiting tuberculocidal properties. The level of biological activity of the synthesized compounds depends on the site of location of the halogen atom.

引用

页码：538 / 541

页数：4