Vitamin D and Otitis Media

被引：3
|
作者：
Walker, Rebecca E. [1 ]
Bartley, Jim [2 ]
Camargo, Carlos A., Jr. [3 ,4 ]
Mitchell, Edwin A. [1 ]
机构：
[1] Univ Auckland, Dept Paediat Child & Youth Hlth, Private Bag 92019, Auckland 1142, New Zealand
[2] Counties Manukau Dist Hlth Board, Div Otolaryngol Head & Neck Surg, Auckland, New Zealand
[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02115 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2019年 / 19卷 / 07期
关键词：
Otitis media; Vitamin D; Viral infections; Respiratory microbiota; Antimicrobial peptides; Cytokines; Biofilms; Upper respiratory tract infections; NF-KAPPA-B; NONTYPABLE HAEMOPHILUS-INFLUENZAE; MIDDLE-EAR; D DEFICIENCY; D-RECEPTOR; ANTIMICROBIAL ACTIVITY; ALLERGIC RHINITIS; D SUPPLEMENTATION; CYTOKINES PRESENT; CHILDREN;
D O I：
10.1007/s11882-019-0866-2
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Purpose of ReviewTo examine the relationship between vitamin D and otitis media.Recent FindingsVitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria.SummaryThis review will explore risk factors of both otitis media and vitamin D deficiency, the evidence of vitamin D being beneficial for various forms of otitis media, and possible mechanisms of action.
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页数：8
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