STALing B cell responses with CD22

被引：3

作者：

Chappell, Craig P. ^{[1
]}

Clark, Edward A. ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 07期

关键词：

PLASMACYTOID DENDRITIC CELLS; ANTIGEN DELIVERY; FACTOR-VIII; T-CELL; ENHANCEMENT; SIGNALS;

D O I：

10.1172/JCI69670

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Suppressing unwanted humoral immune responses without compromising the host's ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system's ability to respond to unrelated antigens.

引用

页码：2778 / 2780

页数：3

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