The role of choline in prostate cancer

被引：70

作者：

Awwad, Hussain Mohamad ^{[1
]}

Geisel, Juergen ^{[1
]}

Obeid, Rima ^{[1
]}

机构：

[1] Saarland Univ Hosp, Dept Clin Chem & Lab Med, D-66421 Homburg, Germany

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 18期

关键词：

Choline; Methyl; Prostate cancer; Phospholipids; ONE-CARBON METABOLISM; GSTP1 CPG ISLAND; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; PHOSPHOLIPASE-D; BREAST-CANCER; CELL-PROLIFERATION; DIETARY CHOLINE; RAS PROTEINS; C-JUN; KINASE;

D O I：

10.1016/j.clinbiochem.2012.08.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Choline is an essential nutrient that is necessary for cell membrane synthesis and phospholipid metabolism and functions as an important methyl donor. Multiple roles for choline in cancer development have been suggested. Choline can affect DNA methylation and lead to a disruption of DNA repair. It can also modify cell signaling that is mediated by intermediary phospholipid metabolites, and it can support the synthesis of cell membranes and thus support cell proliferation. A higher intake or status of choline in plasma and tissues has been related to higher cancer risks. Prostate cancer shows elevated levels of choline uptake and levels of certain choline metabolites. Choline metabolites can be used as potential prognostic biomarkers for the management of prostate cancer patients. Targeting certain enzymes, which are related to choline metabolism, provides promising therapeutic opportunities for tumor growth arrest. This review summarizes the potential role of choline metabolism in cancer, especially in prostate cancer. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1548 / 1553

页数：6

共 50 条

[31] The role of diet in breast and prostate cancer survival
Ferdowsian, Hope R.
Barnard, Neal D.
ETHNICITY & DISEASE, 2007, 17 (02) : S18 - S22
[32] Choline PET/CT for prostate cancer: Main clinical applications
Fuccio, Chiara
Rubello, Domenico
Castellucci, Paolo
Marzola, Maria Cristina
Fanti, Stefano
EUROPEAN JOURNAL OF RADIOLOGY, 2011, 80 (02) : E50 - E56
[33] The role of cyclins in the development and progression of prostate cancer
Dulinska-Litewka, Joanna
Felkle, Dominik
Dykas, Kacper
Handziuk, Zuzanna
Krzysztofik, Marta
Gasiorkiewicz, Bartosz
BIOMEDICINE & PHARMACOTHERAPY, 2022, 155
[34] Role of the Adiponectin Leptin Ratio in Prostate Cancer
Grossmann, Michael E.
Mizuno, Nancy K.
Bonorden, Melissa J. L.
Ray, Amitabha
Sokolchik, Irina
Narasimhan, Meena L.
Cleary, Margot P.
ONCOLOGY RESEARCH, 2009, 18 (5-6) : 269 - 277
[35] Role of MicroRNAs in Treatment Response in Prostate Cancer
Razdan, Anshuli
de Souza, Paul
Roberts, Tara Laurine
CURRENT CANCER DRUG TARGETS, 2018, 18 (10) : 929 - 944
[36] The Potential Role of Exosomal Proteins in Prostate Cancer
Feng, Shangzhi
Lou, Kecheng
Zou, Xiaofeng
Zou, Junrong
Zhang, Guoxi
FRONTIERS IN ONCOLOGY, 2022, 12
[37] The role of calcium channels in prostate cancer progression and potential as a druggable target for prostate cancer treatment
Daba, Motuma Yigezu
Fan, Zhijie
Li, Qinyu
Yuan, Xianglin
Liu, Bo
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2023, 186
[38] Differential role of TRP channels in prostate cancer
Prevarskaya, N.
Flourakis, M.
Bidaux, G.
Thebault, S.
Skryma, R.
BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 : 133 - 135
[39] The Controversial Relationship Between Benign Prostatic Hyperplasia and Prostate Cancer: The Role of Inflammation
De Nunzio, Cosimo
Kramer, Gero
Marberger, Michael
Montironi, Rodolfo
Nelson, William
Schroder, Fritz
Sciarra, Alessandro
Tubaro, Andrea
EUROPEAN UROLOGY, 2011, 60 (01) : 106 - 117
[40] Potential role of CXCR3 in proliferation and invasion of prostate cancer cells
Shen, Daqing
Cao, Xianxiang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (07): : 8091 - 8098

← 1 2 3 4 5 →