Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation

被引：35

作者：

Greenwood-Van Meerveld, B ^{[1
]}

Johnson, AC

Schulkin, J

Myers, DA

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Neurosci, Oklahoma City, OK 73104 USA

[2] Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

[3] Georgetown Univ, Dept Physiol & Biophys, Washington, DC 20016 USA

[4] NIMH, Clin Neuroendocrinol Branch, Bethesda, MD USA

[5] Univ Oklahoma, Hlth Sci Ctr, Dept Obstet & Gynecol, Oklahoma City, OK 73104 USA

来源：

BRAIN RESEARCH | 2006年 / 1071卷 / 01期

关键词：

stress; post-inflammatory; corticotropin-releasing factor; paraventricular nucleus of the hypothalamus;

D O I：

10.1016/j.brainres.2005.11.071

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the long-term effects of an acute colitis on central corticotropin-releasing factor (CRF) expression. An increase in CRF mRNA in the paraventricular nucleus of the hypothalamus (PVN) and the central nucleus of the amygdala (CeA) was observed during active colitis, and the effect in the PVN was maintained following recovery. In summary, hypothalamic gene expression of CRF persists in the PVN despite resolution of an acute colitis. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：91 / 96

页数：6

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