Progress in Synthesis of Nitrogen Heterocycles Catalyzed by Chiral Phosphine

Chiral aza-heterocycles are important molecular skeletons of organic chemistry, which are extensively found in pharmaceuticals, pesticides and biologically active natural products. As a significant organic chemistry research filed, the development of efficient novel synthetic methods of them has been a challenge. Among these strategies for the synthesis of aza-heterocycles compounds, chiral phosphine organocatalysis provides a practical and powerful platform. The recent progress in synthesis of chiral nitrogen heterocycles catalyzed by chiral phosphine is summarized, and the development of this field is also prospected.