Formulation and in vitro Evaluation of Floating Capsules of Theophylline

被引：10

作者：

Bhise, S. B. ^{[1
]}

Aloorkar, N. H. ^{[2
]}

机构：

[1] Govt Coll Pharm, Karad 415124, India

[2] Satara Coll Pharm, Dept Pharmaceut, Satara 415004, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 70卷 / 02期

关键词：

Theophylline; floating drug delivery system; sustained release;

D O I：

10.4103/0250-474X.41460

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sustained release floating capsules for theophylline were fabricated using drug: polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h.

引用

页码：224 / U2

页数：4