Disruption of metabolic pathways - Perspectives for the treatment of cancer

被引：12
作者：
Araujo, EP [1 ]
Carvalheira, JB [1 ]
Velloso, LA [1 ]
机构：
[1] Univ Estadual Campinas, FCM, DCM, Dept Internal Med, BR-13084970 Campinas, SP, Brazil
来源：
CURRENT CANCER DRUG TARGETS | 2006年 / 6卷 / 01期
关键词：
D O I：
10.2174/156800906775471734
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Several growth-promoting signaling pathways have tight molecular connections with metabolic-related signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energy-acquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.
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收藏
页码：77 / 87
页数：11
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