Differential mass spectrometry of rat plasma reveals proteins that are responsive to 17β-estradiol and a selective estrogen receptor modulator PPT

被引：8

作者：

Zhao, Xuemei ^{[1
]}

Deyanova, Ekaterina G. ^{[1
]}

Lubbers, Laura S. ^{[2
]}

Zafian, Pete ^{[2
]}

Li, Jenny J. ^{[1
]}

Liaw, Andy ^{[3
]}

Song, Qinghua ^{[3
]}

Du, Yi ^{[1
]}

Settlage, Robert E. ^{[1
]}

Hickey, Gerry J. ^{[2
]}

Yates, Nathan A. ^{[1
]}

Hendrickson, Ronald C. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Prote, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Pharmacol, Rahway, NJ 07065 USA

[3] Merck Res Labs, Biometr Res, Rahway, NJ 07065 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2008年 / 7卷 / 10期

关键词：

17; beta-estradiol; estrogen receptor; mass spectrometry; PPT; proteomics; plasma protein; N-linked glycoproteins;

D O I：

10.1021/pr800309z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) alpha and beta. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17 beta-estradiol (E2) or an ER alpha-selective agonist PPT by differential mass spectrometry. Our comparative proteomic experiment identifies novel E2- and PPT-responsive proteins, such as serine protease inhibitor family members.

引用

页码：4373 / 4383

页数：11

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