Gold Nanoparticle Uptake by Tumour Cells of B16 Mouse Melanoma

被引：6

作者：

Avram, Marioara ^{[1
]}

Balan, Catalin Mihai ^{[1
]}

Petrescu, Ina ^{[2
]}

Schiopu, Vasilica ^{[1
]}

Marculescu, Catalin ^{[1
]}

Avram, Andrei ^{[1
,3
]}

机构：

[1] Natl Inst Res & Dev Microtechnol, Micro & Nano Fluid Lab L10, Bucharest, Romania

[2] Emergency Univ Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest, Romania

[3] Univ Politehn Bucuresti, Bucharest, Romania

来源：

PLASMONICS | 2012年 / 7卷 / 04期

关键词：

B16; melanoma; UV spectrum; Gold nanoparticles; Plasmon resonance; CELLULAR UPTAKE; SIZE;

D O I：

10.1007/s11468-012-9363-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Because of their photo-optical distinctiveness and biocompatibility, gold nanoparticles have proven to be powerful tools in various nanomedical applications. In this article, we discuss the advantage of gold nanoparticles in image diagnostic application of melanoma. It has demonstrated the potential role of gold nanoparticles in the study of tumour tissue architecture and the utility of gold nanoparticles in the hystopathological exam of B16 melanoma with the benefit of fluorescence emission of gold nanoparticles in UV spectrum. The optical properties of colloidal gold nanoparticles allow spectroscopic detection and identification of melanoma cells. The method proposed is easy, inexpensive and reliable for hystopathological analysis of melanoma. The fluorescence images in the cryosections of tissues depicted a strong luminescence property of gold nanoparticles uptaken in melanoma, results that confirm the role of the gold nanoparticles in biological labelling and imaging applications. To emphasize the AuNPs influence over the biological tissues, a study of the chemical bonds configuration was performed using Raman spectrometry.

引用

页码：717 / 724

页数：8

共 21 条

[1]

Alvarez MM, 1997, J PHYS CHEM B, V101, P3713

[2]

[Anonymous], 2008, TRANSITION METAL NAN

[3] Gold nanoparticles inhibit the proliferation of multiple myeloma cells [J].

Bhattacharya, Resham ;

Patra, Chitta Ranjan ;

Verma, Rajanshu ;

Kumar, Shaji ;

Greipp, Philip R. ;

Mukherjee, Priyabrata .

ADVANCED MATERIALS, 2007, 19 (05) :711-+

[4] Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes [J].

Chithrani, B. Devika ;

Chan, Warren C. W. .

NANO LETTERS, 2007, 7 (06) :1542-1550

[5] Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].

Chithrani, BD ;

Ghazani, AA ;

Chan, WCW .

NANO LETTERS, 2006, 6 (04) :662-668

[6] Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].

Daniel, MC ;

Astruc, D .

CHEMICAL REVIEWS, 2004, 104 (01) :293-346

[7]

De Dror S, 2010, MODERN INTRO SURFACE, P95

[8]

Francis LS, 2007, CHEM ENG PROG, V103, P33

[9] Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine model [J].

Gareau, Daniel S. ;

Merlino, Glenn ;

Corless, Christopher ;

Kulesz-Martin, Molly ;

Jacques, Steven L. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (09) :2184-2190

[10] Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles [J].

Giljohann, David A. ;

Seferos, Dwight S. ;

Patel, Pinal C. ;

Millstone, Jill E. ;

Rosi, Nathaniel L. ;

Mirkin, Chad A. .

NANO LETTERS, 2007, 7 (12) :3818-3821

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