Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

被引：35

作者：

Verweij, Paul E. ^{[1
,2
,3
,10
]}

Arendrup, Maiken C. ^{[4
,5
,9
]}

Alastruey-Izquierdo, Ana ^{[6
]}

Gold, Jeremy A. W. ^{[7
]}

Lockhart, Shawn R. ^{[7
]}

Chiller, Tom ^{[7
]}

White, P. Lewis ^{[8
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboudumc, CWZ Ctr Expertise Mycol, Nijmegen, Netherlands

[3] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Res Diagnost & Lab Surveillance, Bilthoven, Netherlands

[4] Unit Mycol, Statens Serum Inst, Copenhagen, Denmark

[5] Univ Hosp, Rigshosp, Dept Med Microbiol, Copenhagen, Denmark

[6] Inst Salud Carlos III, Mycol Reference Lab, Madrid, Spain

[7] CDCP, Mycot Dis Branch, Atlanta, GA USA

[8] Publ Hlth Wales Mycol Reference Lab, Cardiff, Wales

[9] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[10] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, POB 9101, NL-6500 HB Nijmegen, Netherlands

来源：

DRUG RESISTANCE UPDATES | 2022年 / 65卷

关键词：

Aspergillus fumigatus; DHODH inhibitor; One Health; triazole resistance; olorofim; ASPERGILLUS-FUMIGATUS; AZOLE RESISTANCE;

D O I：

10.1016/j.drup.2022.100885

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

引用

页数：4

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