Cross-reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan

被引:3
作者
Uno, Shingo [1 ]
Kimachi, Kazuhiko [2 ]
Matsuo, Fujio [3 ]
Miyazaki, Keiichiro
Oohama, Ayano
Kei, Junko
Nishimura, Tomohiro [2 ]
Odoh, Koichi
Kino, Yoichiro [2 ]
机构
[1] Chemoserotherapeut Res Inst Kaketsuken, Mkt & Adm Dept, Kita Ku, Kumamoto 8608568, Japan
[2] Chemoserotherapeut Res Inst Kaketsuken, Kikuchi Res Ctr, Kumamoto 8691298, Japan
[3] Statcom, Tokyo 1130034, Japan
关键词
cross-reactive antibody response; longitudinal study; pandemic H1N1 2009 vaccine; seasonal influenza vaccine; INFECTION; PROTECTION; RECEIPT;
D O I
10.1111/j.1348-0421.2012.00511.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 20072008 season but not in the other two seasons. The proportion of individuals with HI antibody titers = 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.
引用
收藏
页码:810 / 816
页数:7
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