Cross-reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan

被引：3

作者：

Uno, Shingo ^{[1
]}

Kimachi, Kazuhiko ^{[2
]}

Matsuo, Fujio ^{[3
]}

Miyazaki, Keiichiro

Oohama, Ayano

Kei, Junko

Nishimura, Tomohiro ^{[2
]}

Odoh, Koichi

Kino, Yoichiro ^{[2
]}

机构：

[1] Chemoserotherapeut Res Inst Kaketsuken, Mkt & Adm Dept, Kita Ku, Kumamoto 8608568, Japan

[2] Chemoserotherapeut Res Inst Kaketsuken, Kikuchi Res Ctr, Kumamoto 8691298, Japan

[3] Statcom, Tokyo 1130034, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2012年 / 56卷 / 12期

关键词：

cross-reactive antibody response; longitudinal study; pandemic H1N1 2009 vaccine; seasonal influenza vaccine; INFECTION; PROTECTION; RECEIPT;

D O I：

10.1111/j.1348-0421.2012.00511.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 20072008 season but not in the other two seasons. The proportion of individuals with HI antibody titers = 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.

引用

页码：810 / 816

页数：7

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