High-Dose Resveratrol Supplementation in Obese Men An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

被引:378
作者
Poulsen, Morten M. [1 ]
Vestergaard, Poul F. [1 ]
Clasen, Berthil F. [1 ]
Radko, Yulia [2 ]
Christensen, Lars P. [2 ]
Stodkilde-Jorgensen, Hans [3 ]
Moller, Niels [1 ]
Jessen, Niels [4 ]
Pedersen, Steen B. [1 ]
Jorgensen, Jens Otto L. [1 ]
机构
[1] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark
[2] Univ Southern Denmark, Inst Chem Engn Biotechnol & Environm Technol, Odense, Denmark
[3] Aarhus Univ Hosp, Magnet Resonance Res Ctr, DK-8000 Aarhus, Denmark
[4] Aarhus Univ Hosp, Dept Pharmacol, DK-8000 Aarhus, Denmark
关键词
HUMAN ADIPOSE-TISSUE; FATTY LIVER-DISEASE; IN-VIVO; CALORIC RESTRICTION; HEALTHY-VOLUNTEERS; GLUCOSE; SIRT1; RATS; RESISTANCE; EXPRESSION;
D O I
10.2337/db12-0975
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce. The objective of this study was to examine the metabolic effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men were randomly assigned to 4 weeks of resveratrol or placebo treatment. Extensive metabolic examinations including assessment of glucose turnover and insulin sensitivity (hyperinsulinemic euglycemic clamp) were performed before and after the treatment. Insulin sensitivity, the primary outcome measure, deteriorated insignificantly in both groups. Endogenous glucose production and the turnover and oxidation rates of glucose remained unchanged. Resveratrol supplementation also had no effect on blood pressure; resting energy expenditure; oxidation rates of lipid; ectopic or visceral fat content; or inflammatory and metabolic biomarkers. The lack of effect disagrees with persuasive data obtained from rodent models and raises doubt about the justification of resveratrol as a human nutritional supplement in metabolic disorders. Diabetes 62:1186-1195, 2013
引用
收藏
页码:1186 / 1195
页数:10
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