Is the Defined Daily Dose system a reliable tool for standardizing antipsychotic dosages?

被引：76

作者：

Nose, Michela ^{[1
]}

Tansella, Michele ^{[1
]}

Thornicroft, Graham ^{[2
]}

Schene, Aart ^{[3
]}

Becker, Thomas ^{[4
,5
]}

Veronese, Antonio ^{[1
]}

Leese, Morven ^{[2
]}

Koeter, Maarten ^{[3
]}

Angermeyer, Matthias ^{[4
]}

Barbui, Corrado ^{[1
]}

机构：

[1] Univ Verona, Dept Med & Publ Hlth, Sect Psychiat & Clin Psychol, Policlin GB Rossi, I-37134 Verona, Italy

[2] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London, England

[3] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Leipzig, Dept Psychiat, Leipzig, Germany

[5] Univ Ulm, Dept Psychiat 2, Bkh Gunzburg, Germany

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2008年 / 23卷 / 05期

关键词：

antipsychotic drug; defined daily dose; schizophrenia;

D O I：

10.1097/YIC.0b013e328303ac75

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was carried out to establish whether the Defined Daily Doses (DDDs) system could be reliably applied to standardize antipsychotic dosages. Initially, the relationship between antipsychotic doses expressed as DDDs, chlorpromazine equivalents (CPZEs) and percentages of the British National Formulary (BNF) maximum recommended daily dose were investigated by calculating Spearman's rank correlation coefficients. Second, factors associated with antipsychotic dose, expressed as DDDs, CPZEs and percentages of the BNF maximum recommended daily dose, were investigated by means of linear regression analysis. The study sample consisted of 277 patients with schizophrenia. The relationship between antipsychotic daily doses expressed as multiples of DDDs and CPZEs revealed a significant correlation (Spearman's p = 0.779, P < 0.001). Similarly, the relationship between antipsychotic daily doses expressed as multiples of DDDs and percentages of the BNF maximum recommended daily dose revealed a significant correlation (Spearman's p = 0.869, P < 0.001). Linear regression analyses highlighted a high degree of coherence between antipsychotic doses expressed as DDDs, CPZEs and percentages of the BNF maximum recommended daily dose. In conclusion, this study found that the DDD system is a reliable tool for standardizing antipsychotic doses in drug utilization research.

引用

页码：287 / 290

页数：4

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