Limonoids and triterpenoid from fruit of Swietenia macrophylla

被引：17
|
作者：
Sun, Yun-Peng [1 ]
Zhu, Li-Li [1 ]
Liu, Jin-song [1 ,2 ]
Yu, Yang [1 ]
Zhou, Zhong-yu [3 ]
Wang, Gang [1 ,2 ]
Wang, Guo-Kai [1 ,2 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230012, Anhui, Peoples R China
[2] Synerget Innovat Ctr Anhui Authent Chinese Med Qu, Hefei 230012, Anhui, Peoples R China
[3] Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Guangdong, Peoples R China
来源：
FITOTERAPIA | 2018年 / 125卷
基金：
中国国家自然科学基金;
关键词：
Swietenia macrophylla; Limonoids; Triterpenoid; Cytotoxicity; MANGROVE; SEEDS;
D O I：
10.1016/j.fitote.2018.01.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new limonoids, swieteliacates A-E (1-5) and a tirucallane-type triterpenoid, swietesenin (6), together with four known compounds (7-10) were isolated from fruit of Swietenia macrophylla. Their structures were determined by spectroscopic analyses. The new compounds were tested in vitro for their cytotoxic effects against five human cancer cell lines. Compound 2 exhibited moderate cytotoxic activities against SW480 and HL-60 cancer cell lines with IC50 values of 30.6 and 32.9 mu M, respectively.
引用
收藏
页码：141 / 146
页数：6
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