Enzyme-based lactic acid detection using AlGaN/GaN high electron mobility transistors with ZnO nanorods grown on the gate region

被引：48

作者：

Chu, B. H. ^{[1
]}

Kang, B. S. ^{[1
]}

Ren, F. ^{[1
]}

Chang, C. Y. ^{[2
]}

Wang, Y. L. ^{[2
]}

Pearton, S. J. ^{[2
]}

Glushakov, A. V. ^{[3
]}

Dennis, D. M. ^{[3
]}

Johnson, J. W. ^{[4
]}

Rajagopal, P. ^{[4
]}

Roberts, J. C. ^{[4
]}

Piner, E. L. ^{[4
]}

Linthicum, K. J. ^{[4
]}

机构：

[1] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA

[3] Univ Florida, Dept Anesthesiol, Gainesville, FL 32610 USA

[4] Nitronex Corp, Raleigh, NC 27606 USA

来源：

APPLIED PHYSICS LETTERS | 2008年 / 93卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2966158

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The detection of lactic acid with ZnO nanorod-gated AlGaN/GaN high electron mobility transistors (HEMTs) was demonstrated. The array of ZnO nanorods provided a large effective surface area with a high surface-to-volume ratio and a favorable environment for the immobilization of lactate oxidase. The HEMT drain-source current showed a rapid response when various concentrations of lactic acid solutions were introduced to the gate area of the HEMT sensor. The HEMT could detect lactic acid concentrations from 167 nM to 139 mu M. Our results show that portable, fast response, and wireless-based lactic acid detectors can be realized with AlGaN/GaN HEMT based sensors. (C) 2008 American Institute of Physics.

引用

页数：3

共 31 条

[1]

AMBACHER O, 2002, P ECS, V214, P27

[2] Direct electrochemistry of lactate dehydrogenase immobilized on silica sol-gel modified gold electrode and its application [J].

Di, Junwei ;

Cheng, Jiongjia ;

Xu, Quan ;

Zheng, Huie ;

Zhuang, Jingyue ;

Sun, Yongbo ;

Wang, Keyu ;

Mo, Xiangyin ;

Bi, Shuping .

BIOSENSORS & BIOELECTRONICS, 2007, 23 (05) :682-687

[3] Zinc oxide nanostructures: Synthesis and properties [J].

Fan, ZY ;

Lu, JG .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2005, 5 (10) :1561-1573

[4] The development of reagentless lactate biosensor based on a novel conducting polymer [J].

Haccoun, J. ;

Piro, B. ;

Noel, V. ;

Pham, M. C. .

BIOELECTROCHEMISTRY, 2006, 68 (02) :218-226

[5] ZnO nanowire growth and devices [J].

Heo, YW ;

Norton, DP ;

Tien, LC ;

Kwon, Y ;

Kang, BS ;

Ren, F ;

Pearton, SJ ;

LaRoche, JR .

MATERIALS SCIENCE & ENGINEERING R-REPORTS, 2004, 47 (1-2) :1-47

[6] Enzymatic glucose detection using ZnO nanorods on the gate region of AlGaN/GaN high electron mobility transistors [J].

Kang, B. S. ;

Wang, H. T. ;

Ren, F. ;

Pearton, S. J. ;

Morey, T. E. ;

Dennis, D. M. ;

Johnson, J. W. ;

Rajagopal, P. ;

Roberts, J. C. ;

Piner, E. L. ;

Linthicum, K. J. .

APPLIED PHYSICS LETTERS, 2007, 91 (25)

[7] Exhaled-breath detection using AlGaN/GaN high electron mobility transistors integrated with a Peltier element [J].

Kang, B. S. ;

Wang, H. T. ;

Ren, F. ;

Gila, B. P. ;

Abernathy, C. R. ;

Pearton, S. J. ;

Dennis, D. M. ;

Johnson, J. W. ;

Rajagopal, P. ;

Roberts, J. C. ;

Piner, E. L. ;

Linthicum, K. J. .

ELECTROCHEMICAL AND SOLID STATE LETTERS, 2008, 11 (03) :J19-J21

[8] Low temperature (<100 °C) patterned growth of ZnO nanorod arrays on Si [J].

Kang, B. S. ;

Pearton, S. J. ;

Ren, F. .

APPLIED PHYSICS LETTERS, 2007, 90 (08)

[9] Electrical detection of immobilized proteins with ungated AlGaN/GaN high-electron-mobility transistors [J].

Kang, BS ;

Ren, F ;

Wang, L ;

Lofton, C ;

Tan, WHW ;

Pearton, SJ ;

Dabiran, A ;

Osinsky, A ;

Chow, PP .

APPLIED PHYSICS LETTERS, 2005, 87 (02)

[10] pH measurements with single ZnO nanorods integrated with a microchannel -: art. no. 112105 [J].

Kang, BS ;

Ren, F ;

Heo, YW ;

Tien, LC ;

Norton, DP ;

Pearton, SJ .

APPLIED PHYSICS LETTERS, 2005, 86 (11) :1-3

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