Comparison of serum FSH and Inhibin B levels between adult male dizygotic and monozygotic twins

被引：1

作者：

Sutcliffe, A ^{[1
]}

Spoudeas, HA

Nair, D

Bouloux, P

Oliver, T

Sambrook, P

Bannister, W

Lambalk, CB

Spector, T

机构：

[1] Royal Free & Univ Coll Med Sch, Dept Child Hlth, London NW3 2PF, England

[2] Royal Free & Univ Coll Med Sch, Dept Chem Pathol, London NW3 2PF, England

[3] Royal Free & Univ Coll Med Sch, Dept Primary Care & Populat Sci, London NW3 2PF, England

[4] UCL, London, England

[5] Great Ormond St Hosp Sick Children, London WC1N 3JH, England

[6] St Bartholomews & Royal London Hosp, London, England

[7] St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London, England

[8] Univ Sydney, Royal N Shore Hosp, St Leonards, NSW 2065, Australia

[9] Vrije Univ Amsterdam, Med Ctr, Div Reprod Med, Amsterdam, Netherlands

来源：

HUMAN REPRODUCTION | 2006年 / 21卷 / 02期

基金：

英国惠康基金;

关键词：

FSH hypersecretion; inhibin B; twins;

D O I：

10.1093/humrep/dei327

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: FSH hypersecretion occurs in mothers of dizygotic (DZ) twins. Twinning is inherited via both sexes and transmitted through the female. FSH hypersecretion may thus occur in male DZ twins. METHODS: We assayed FSH and its counter-regulatory hormone, Inhibin B, in 108 adult male DZ and 100 monozygotic (MZ) twins (as controls) and compared our results to published norms. RESULTS: Inhibin B was elevated and higher in DZ compared with MZ twins with similar FSH. CONCLUSION: The normal FSH: Inhibin B endocrine feedback axis is different in adult male DZ twins. This contributes to the theory that the answer to human DZ twinning lies in the actions of FSH and Inhibin, and in their mutual interaction.

引用

页码：447 / 450

页数：4

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