Dynamic host immune response in virus-associated cancers

被引：40

作者：

Cao, Song ^{[1
,2
]}

Wylie, Kristine M. ^{[2
,3
]}

Wyczalkowski, Matt A. ^{[1
,2
]}

Karpova, Alla ^{[1
]}

Ley, Jessica ^{[4
]}

Sun, Sam ^{[1
,2
]}

Mashl, R. Jay ^{[1
,2
]}

Liang, Wen-Wei ^{[1
,2
]}

Wang, Xiaowei ^{[5
,6
]}

Johnson, Kimberly ^{[7
]}

DiPersio, John F. ^{[1
,4
]}

Gay, Hiram ^{[4
]}

Ratner, Lee ^{[1
]}

Chen, Feng ^{[1
,4
]}

Adkins, Douglas R. ^{[1
,4
]}

Ding, Li ^{[1
,2
,4
,8
]}

机构：

[1] Washington Univ, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, McDonnell Genome Inst, St Louis, MO 63108 USA

[3] Washington Univ, Dept Pediat, St Louis, MO 63110 USA

[4] Washington Univ, Siteman Canc Ctr, St Louis, MO 63110 USA

[5] Washington Univ, Dept Radiat Oncol, St Louis, MO 63110 USA

[6] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

[7] Washington Univ, Brown Sch Master Publ Hlth Program, St Louis, MO 63130 USA

[8] Washington Univ, Dept Genet, St Louis, MO 63110 USA

来源：

COMMUNICATIONS BIOLOGY | 2019年 / 2卷 / 1期

关键词：

SQUAMOUS-CELL CARCINOMA; HPV-ASSOCIATED HEAD; PD-L1; EXPRESSION; POSITIVE HEAD; T-CELLS; GENE; RECEPTOR; BREAST; MUTATIONS; PATHWAY;

D O I：

10.1038/s42003-019-0352-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viruses drive carcinogenesis in human cancers through diverse mechanisms that have not been fully elucidated but include promoting immune escape. Here we investigated associations between virus-positivity and immune pathway alteration for 2009 tumors across six virus-related cancer types. Analysis revealed that for 3 of 72 human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSC) the HPV genome integrated in immune checkpoint genes PD-L1 or PD-L2, driving elevated expression in the corresponding gene. In addition to the previously described upregulation of the PD-1 immunosuppressive pathway in Epstein-Barr virus (EBV)-positive stomach tumors, we also observed upregulation of the PD-1 pathway in cytomegalovirus (CMV)-positive tumors. Furthermore, we found signatures of T-cell and B-cell response in HPV-positive HNSC and EBV-positive stomach tumors and HPV-positive HNSC patients were associated with better survival when T-cell signals were detected. Our work reveals that viral infection may recruit immune effector cells, and upregulate PD-1 and CTLA-4 immunosuppressive pathways.

引用

页数：11

共 69 条

[1] Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors [J].

Akbay, Esra A. ;

Koyama, Shohei ;

Carretero, Julian ;

Altabef, Abigail ;

Tchaicha, Jeremy H. ;

Christensen, Camilla L. ;

Mikse, Oliver R. ;

Cherniack, Andrew D. ;

Beauchamp, Ellen M. ;

Pugh, Trevor J. ;

Wilkerson, Matthew D. ;

Fecci, Peter E. ;

Butaney, Mohit ;

Reibel, Jacob B. ;

Soucheray, Margaret ;

Cohoon, Travis J. ;

Janne, Pasi A. ;

Meyerson, Matthew ;

Hayes, D. Neil ;

Shapiro, Geoffrey I. ;

Shimamura, Takeshi ;

Sholl, Lynette M. ;

Rodig, Scott J. ;

Freeman, Gordon J. ;

Hammerman, Peter S. ;

Dranoff, Glenn ;

Wong, Kwok-Kin .

CANCER DISCOVERY, 2013, 3 (12) :1355-1363

[2]

[Anonymous], VIRUSSCAN PIPELINE

[3] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections [J].

Appay, V ;

Dunbar, PR ;

Callan, M ;

Klenerman, P ;

Gillespie, GMA ;

Papagno, L ;

Ogg, GS ;

King, A ;

Lechner, F ;

Spina, CA ;

Little, S ;

Havlir, DV ;

Richman, DD ;

Gruener, N ;

Pape, G ;

Waters, A ;

Easterbrook, P ;

Salio, M ;

Cerundolo, V ;

McMichael, AJ ;

Rowland-Jones, SL .

NATURE MEDICINE, 2002, 8 (04) :379-385

[4] Systematic pan-cancer analysis of tumour purity [J].

Aran, Dvir ;

Sirota, Marina ;

Butte, Atul J. .

NATURE COMMUNICATIONS, 2015, 6

[5] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[6] PD-1-Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer [J].

Badoual, Cecile ;

Hans, Stephane ;

Merillon, Nathalie ;

Van Ryswick, Cordelia ;

Ravel, Patrice ;

Benhamouda, Nadine ;

Levionnois, Emeline ;

Nizard, Mevyn ;

Si-Mohamed, Ali ;

Besnier, Nicolas ;

Gey, Alain ;

Rotem-Yehudar, Rinat ;

Pere, Helene ;

Tran, Thi ;

Guerin, Coralie L. ;

Chauvat, Anne ;

Dransart, Estelle ;

Alanio, Cecile ;

Albert, Sebastien ;

Barry, Beatrix ;

Sandoval, Federico ;

Quintin-Colonna, Francoise ;

Bruneval, Patrick ;

Fridman, Wolf H. ;

Lemoine, Francois M. ;

Oudard, Stephane ;

Johannes, Ludger ;

Olive, Daniel ;

Brasnu, Daniel ;

Tartour, Eric .

CANCER RESEARCH, 2013, 73 (01) :128-138

[7] FOXA1 expression in breast cancer - Correlation with luminal subtype A and survival [J].

Badve, Sunil ;

Turbin, Dmitry ;

Thorat, Mangesh A. ;

Morimiya, Akira ;

Nielsen, Torsten O. ;

Perou, Charles M. ;

Dunn, Sandi ;

Huntsman, David G. ;

Nakshatri, Harikrishna .

CLINICAL CANCER RESEARCH, 2007, 13 (15) :4415-4421

[8] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[9] Analysis of colorectal cancers for human cytomegalovirus presence [J].

Bender C. ;

Zipeto D. ;

Bidoia C. ;

Costantini S. ;

Zamo A. ;

Menestrina F. ;

Bertazzoni U. .

Infectious Agents and Cancer, 4 (1)

[10] Divergent viral presentation among human tumors and adjacent normal tissues [J].

Cao, Song ;

Wendl, Michael C. ;

Wyczalkowski, Matthew A. ;

Wylie, Kristine ;

Ye, Kai ;

Jayasinghe, Reyka ;

Xie, Mingchao ;

Wu, Song ;

Niu, Beifang ;

Grubb, Robert, III ;

Johnson, Kimberly J. ;

Gay, Hiram ;

Chen, Ken ;

Rader, Janet S. ;

Dipersio, John F. ;

Chen, Feng ;

Ding, Li .

SCIENTIFIC REPORTS, 2016, 6

← 1 2 3 4 5 6 7 →