Ammosamide D, an Oxidatively Ring Opened Ammosamide Analog from a Marine-Derived Streptomyces variabilis

被引：35

作者：

Pan, Ende ^{[1
]}

Jamison, Matthew ^{[1
]}

Yousufuddin, Muhammed ^{[2
]}

MacMillan, John B. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Div Chem, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas Arlington, Ctr Nanostruct Mat, Dept Chem, Arlington, TX 76019 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 09期

关键词：

LYMPHOSTIN LK6-A; SP KY11783; IMMUNOSUPPRESSANT;

D O I：

10.1021/ol300806e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ammosamide D (1), an oxidized analog of the ammosamide family, was isolated from a marine-derived Streptomyces variabilis. Pyrroloquinoline containing alkaloids are a growing class of natural products, with 1 being the first example of an oxidized analog resulting In a 5,6-dioxo-5,6-dihydroquinoline ring system. Attempts at chemical conversion of ammosamide B to ammosamide D revealed that a strong chemical oxidant Is required. Ammosamide D has modest cytotoxicity to the MIA PaCa-2 pancreatic cancer cell line.

引用

页码：2390 / 2393

页数：4

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