Neurological perspectives on voltage-gated sodium channels

被引：255

作者：

Eijkelkamp, Niels ^{[1
]}

Linley, John E. ^{[1
]}

Baker, Mark D. ^{[2
]}

Minett, Michael S. ^{[1
]}

Cregg, Roman ^{[1
]}

Werdehausen, Robert ^{[1
,3
]}

Rugiero, Francois ^{[1
]}

Wood, John N. ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, London WC1E 6BT, England

[2] Neurosci Inst Cell & Mol Sci Barts & London Sch M, London E1 2AT, England

[3] Univ Dusseldorf, Fac Med, Dept Anaesthesiol, D-40225 Dusseldorf, Germany

来源：

BRAIN | 2012年 / 135卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

ion channel; genetics; pain; epilepsy; SCN1A; EXTREME PAIN DISORDER; SEVERE MYOCLONIC EPILEPSY; SPINAL SENSORY NEURONS; PERSISTENT NA+ CURRENT; FEBRILE SEIZURES-PLUS; GATING CHARGE MOVEMENT; ROOT GANGLION NEURONS; OF-FUNCTION MUTATIONS; TETRODOTOXIN-RESISTANT; NEUROPATHIC PAIN;

D O I：

10.1093/brain/aws225

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.

引用

页码：2585 / 2612

页数：28

共 339 条

[1] The cell and molecular basis of mechanical, cold, and inflammatory pain
Abrahamsen, Bjarke
Zhao, Jing
Asante, Curtis O.
Cendan, Cruz Miguel
Marsh, Steve
Martinez-Barbera, Juan Pedro
Nassar, Mohammed A.
Dickenson, Anthony H.
Wood, John N.
[J]. SCIENCE, 2008, 321 (5889) : 702 - 705
[2] A stop codon mutation in SCN9A causes lack of pain sensation
Ahmad, Sultan
Dahllund, Leif
Eriksson, Anders B.
Hellgren, Dennis
Karlsson, Urban
Lund, Per-Eric
Meijer, Inge A.
Meury, Luc
Mills, Tracy
Moody, Adrian
Morinville, Anne
Morten, John
O'Donnell, Dajan
Raynoschek, Carina
Salter, Hugh
Rouleau, Guy A.
Krupp, Johannes J.
[J]. HUMAN MOLECULAR GENETICS, 2007, 16 (17) : 2114 - 2121
[3] The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
Akopian, AN
Souslova, V
England, S
Okuse, K
Ogata, N
Ure, J
Smith, A
Kerr, BJ
McMahon, SB
Boyce, S
Hill, R
Stanfa, LC
Dickenson, AH
Wood, JN
[J]. NATURE NEUROSCIENCE, 1999, 2 (06) : 541 - 548
[4] A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
Akopian, AN
Sivilotti, L
Wood, JN
[J]. NATURE, 1996, 379 (6562) : 257 - 262
[5] Portability of paddle motif function and pharmacology in voltage sensors
Alabi, AbdulRasheed A.
Bahamonde, Maria Isabel
Jung, Hoi Jong
Kim, Jae Il
Swartz, Kenton J.
[J]. NATURE, 2007, 450 (7168) : 370 - +
[6] ALZHEIMER C, 1993, J NEUROSCI, V13, P660
[7] The voltage-gated sodium channel Nav1.9 is an effector of peripheral inflammatory pain hypersensitivity
Amaya, Fumimasa
Wang, Haibin
Costigan, Michael
Allchorne, Andrew J.
Hatcher, Jon P.
Egerton, Julie
Stean, Tania
Morisset, Valerie
Grose, David
Gunthorpe, Martin J.
Chessell, Iain P.
Tate, Simon
Green, Paula J.
Woolf, Clifford J.
[J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (50) : 12852 - 12860
[8] Na channel inactivation from open and closed states
Armstrong, Clay M.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (47) : 17991 - 17996
[9] Voltage-gated ion channels and electrical excitability
Armstrong, CM
Hille, B
[J]. NEURON, 1998, 20 (03) : 371 - 380
[10] New SCN5A mutation in a SUDEP victim with idiopathic epilepsy
Aurlien, Dag
Leren, Trond P.
Tauboll, Erik
Gjerstad, Leif
[J]. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2009, 18 (02): : 158 - 160

← 1 2 3 4 5 6 7 8 9 10 →