The first ratiometric fluorescent probes for aminopeptidase N cell imaging

被引：47

作者：

Chen, Laizhong ^{[1
]}

Sun, Wei ^{[1
]}

Li, Jing ^{[1
]}

Liu, Zhenzhen ^{[1
]}

Ma, Zhao ^{[1
]}

Zhang, Wei ^{[1
]}

Du, Lupei ^{[1
]}

Xu, Wenfang ^{[1
]}

Fang, Hao ^{[1
]}

Li, Minyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Key Lab Chem Biol Nat Prod MOE, Sch Pharm, Jinan 250012, Shandong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 02期

关键词：

NGR; BINDING; TARGET; MOTIF; CD13;

D O I：

10.1039/c2ob26564h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. As a result, these molecules were successfully identified as the first ratiometric fluorescent probes for APN cell imaging.

引用

收藏

页码：378 / 382

页数：5

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