Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: Access, formulations, generics, therapeutic drug monitoring, and special populations

被引：15

作者：

Cochrane, Adam B. ^{[1
]}

Lyster, Haifa ^{[2
]}

Lindenfeld, JoAnn ^{[3
]}

Doligalski, Christina ^{[4
]}

Baran, David ^{[5
]}

Yost, Colleen ^{[6
]}

Shullo, Michael ^{[7
]}

Schweiger, Martin ^{[8
]}

Weill, David ^{[9
]}

Stuckey, Linda ^{[10
]}

Ivulich, Steven ^{[11
]}

Scheel, Janet ^{[12
]}

Peters, Lisa ^{[13
]}

Colvin, Monica ^{[14
]}

Dawson, Kyle ^{[15
]}

Girgis, Reda ^{[16
]}

Weeks, Phillip ^{[17
]}

Tse, Tracy ^{[18
]}

Russell, Stuart ^{[19
]}

Flattery, Maureen ^{[20
]}

Jennings, Doug ^{[21
]}

Kittleson, Michelle ^{[22
]}

Miller, Tara ^{[19
]}

Khuu, Tam ^{[23
]}

Claridge, Tamara ^{[24
]}

Uber, Patricia ^{[25
]}

Ford, Katrina ^{[26
]}

Ensor, Christopher R. ^{[27
]}

Simpson, Kathleen ^{[28
]}

Dipchand, Anne ^{[29
]}

Page, Robert L., II ^{[30
]}

机构：

[1] Inova Fairfax Hosp, Falls Church, VA 22042 USA

[2] Royal Brompton & Harefield Hosp NHS Fdn Trust, London, England

[3] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA

[4] Univ North Carolina Hlth Syst, Chapel Hill, NC USA

[5] Sentara Norfolk Gen Hosp, Eastern Virginia Med Sch, Norfolk, VA USA

[6] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[7] West Virginia Univ Hlth Syst, Morgantown, WV USA

[8] Univ Childrens Hosp Zurich, Zurich, Switzerland

[9] Weill Consulting Grp, New Orleans, LA USA

[10] Univ Michigan Hlth Syst, Ann Arbor, MI USA

[11] Alfred Hosp, Melbourne, Vic, Australia

[12] Washington Univ, St Louis Childrens Hosp, Sch Med, St Louis, MO 63110 USA

[13] Washington Hosp Ctr, Washington, DC 20010 USA

[14] Univ Michigan, Sch Med, Ann Arbor, MI USA

[15] Univ Kentucky Hlth Syst, Lexington, KY USA

[16] Spectrum Hlth Syst, Grand Rapids, MI USA

[17] Mem Hermann Texas Med Ctr, Houston, TX USA

[18] Queensland Hlth, Chermside, Australia

[19] Duke Univ Hlth Syst, Durham, NC USA

[20] Virginia Commonwealth Univ Hlth Syst, Richmond, VA USA

[21] Columbia Univ Hlth Syst, New York, NY USA

[22] Cedars Sinai Hlth Syst, Los Angeles, CA USA

[23] Univ Calif Los Angeles, Los Angeles, CA USA

[24] Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA

[25] Tampa Gen Hosp, Tampa, FL 33606 USA

[26] Great Ormond St Hosp Sick Children, London, England

[27] AdventHealth, Orlando, FL USA

[28] Washington Univ, St Louis, MO 63110 USA

[29] Hosp Sick Children, Toronto, ON, Canada

[30] Univ Colorado, Sch Pharm, Denver, CO 80202 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2020年 / 39卷 / 10期

关键词：

heart transplantation; lung transplantation; immunosuppression; pediatric transplantation; generic immunosuppression; PROTON PUMP INHIBITORS; COATED MYCOPHENOLATE SODIUM; RENAL-ALLOGRAFT RECIPIENTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; MULTISITE ANALYTICAL EVALUATION; ANTIBODY-MEDIATED REJECTION; UNDER-THE-CURVE; DE-NOVO LUNG; HEART-TRANSPLANTATION; INTERNATIONAL SOCIETY;

D O I：

10.1016/j.healun.2020.06.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2009, the International Society for Heart and Lung Transplantation recognized the importance and challenges surrounding generic drug immunosuppression. As experience with generics has expanded and comfort has increased, substantial issues have arisen since that time with other aspects of immunomodulation that have not been addressed, such as access to medicines, alternative immunosuppression formulations, additional generics, implications on therapeutic drug monitoring, and implications for special populations such as pediatrics and older adults. The aim of this consensus document is to address critically each of these concerns, expand on the challenges and barriers, and provide therapeutic considerations for practitioners who manage patients who need to undergo or have undergone cardiothoracic transplantation. (C) 2020 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：1050 / 1069

页数：20

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