Prevalence of coeliac disease in Turner syndrome

被引:50
作者
Ivarsson, SA [1 ]
Carlsson, A
Bredberg, A
Alm, J
Aronsson, S
Gustafsson, J
Hagenäs, L
Häger, A
Kriström, B
Marcus, C
Moëll, C
Nilsson, KO
Tuvemo, T
Westphal, O
Albertsson-Wikland, K
Aman, J
机构
[1] Univ Lund, Dept Paediat, Malmo Univ Hosp, S-20502 Malmo, Sweden
[2] Univ Lund, Dept Bacteriol, Malmo Univ Hosp, S-20502 Malmo, Sweden
[3] Univ Gothenburg, Dept Paediat, Gothenburg, Sweden
[4] Linkoping Univ, Dept Paediat, Linkoping, Sweden
[5] Umea Univ, Dept Paediat, Umea, Sweden
[6] Uppsala Univ, Dept Paediat, Uppsala, Sweden
[7] Karolinska Hosp, Dept Paediat, S-10401 Stockholm, Sweden
[8] Huddinge Hosp, Stockholm, Sweden
[9] Cent Hosp, Halmstad, Sweden
[10] Cent Hosp, Orebro, Sweden
关键词
coeliac disease; IgA-antiendomysium antibodies; IgA-antigliadin antibodies; Turner syndrome;
D O I
10.1080/08035259950168397
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.
引用
收藏
页码:933 / 936
页数:4
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