Prevalence of coeliac disease in Turner syndrome

被引：50

作者：

Ivarsson, SA ^{[1
]}

Carlsson, A

Bredberg, A

Alm, J

Aronsson, S

Gustafsson, J

Hagenäs, L

Häger, A

Kriström, B

Marcus, C

Moëll, C

Nilsson, KO

Tuvemo, T

Westphal, O

Albertsson-Wikland, K

Aman, J

机构：

[1] Univ Lund, Dept Paediat, Malmo Univ Hosp, S-20502 Malmo, Sweden

[2] Univ Lund, Dept Bacteriol, Malmo Univ Hosp, S-20502 Malmo, Sweden

[3] Univ Gothenburg, Dept Paediat, Gothenburg, Sweden

[4] Linkoping Univ, Dept Paediat, Linkoping, Sweden

[5] Umea Univ, Dept Paediat, Umea, Sweden

[6] Uppsala Univ, Dept Paediat, Uppsala, Sweden

[7] Karolinska Hosp, Dept Paediat, S-10401 Stockholm, Sweden

[8] Huddinge Hosp, Stockholm, Sweden

[9] Cent Hosp, Halmstad, Sweden

[10] Cent Hosp, Orebro, Sweden

来源：

ACTA PAEDIATRICA | 1999年 / 88卷 / 09期

关键词：

coeliac disease; IgA-antiendomysium antibodies; IgA-antigliadin antibodies; Turner syndrome;

D O I：

10.1080/08035259950168397

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.

引用

页码：933 / 936

页数：4

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