Synthesis and antimicrobial activity of 4-substituted thiazol-2-yl hydrazine derivatives of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carbaldehyde

The manuscript reports synthesis and antimicrobial activity of several novel heterocyclic compounds in which 1,4-disubstituted 1,2,3-triazole synthesized via click chemistry approach and 4-aryl (5a-h) and 4-piperazinyl amide (7a-e) or 4-aryl amide (8a-e) substituted thiazole rings, are bridged through hydrazine linkage. Structures of all the synthesized compounds have been elucidated using H-1 and C-13 NMR and mass spectral analysis. In vitro antimicrobial screening of the target compounds has been carried out against six bacterial species viz. E. coli, P. aeruginosa, B. subtilis, S. pyogenes, K. pneumoniae and S. aureus and four fungal species viz. C. albicans, T. viride, A. flavus and A. brasiliensis. The activity study revealed that many of the compounds possess moderate to good activity against the tested microorganisms. The active compounds have been further studied to determine the minimum inhibitory concentration (MIC).