Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache

被引：86
作者：
Bo, S. H. [2 ,3 ]
Davidsen, E. M. [2 ]
Gulbrandsen, P. [3 ,4 ]
Dietrichs, E. [4 ,5 ]
Bovim, G. [6 ]
Stovner, L. J. [6 ,7 ]
White, L. R. [1 ,6 ]
机构：
[1] Univ Trondheim Hosp, Dept Neurol & Clin Neurophysiol, Neurobiol Lab, N-7006 Trondheim, Norway
[2] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
[3] Helse Sor Ost Hlth Serv Res Ctr, Lorenskog, Norway
[4] Univ Oslo, Fac Med, Oslo, Norway
[5] Univ Hosp, Rikshosp, Ctr Clin Neurosci, Dept Neurol, Oslo, Norway
[6] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway
[7] Norwegian Univ Sci & Technol, Fac Med, Norwegian Natl Headache Ctr, N-7034 Trondheim, Norway
来源：
CEPHALALGIA | 2009年 / 29卷 / 03期
关键词：
Cytokines; cerebrospinal fluid; migraine; episodic tension-type hedache; cervicogenic headache; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-NECROSIS-FACTOR; PROINFLAMMATORY CYTOKINES; FACTOR-ALPHA; EXPRESSION; INTERLEUKIN-1; MOLECULES; SCLEROSIS; RESPONSES; TRIGGERS;
D O I：
10.1111/j.1468-2982.2008.01727.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [interleukin (IL)-1 beta, tumour necrosis factor-alpha and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-beta 1 (TGF-beta 1)] were included. There were significant group differences in IL-1ra, TGF-beta 1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-beta 1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache.
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收藏
页码：365 / 372
页数：8
相关论文
共 35 条
[1]   Cervicogenic headache: evaluation of the original diagnostic criteria [J].
Antonaci, F ;
Ghirmai, S ;
Bono, G ;
Sandrini, G ;
Nappi, G .
CEPHALALGIA, 2001, 21 (05) :573-583
[2]   Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model [J].
Bolay, H ;
Reuter, U ;
Dunn, AK ;
Huang, ZH ;
Boas, DA ;
Moskowitz, MA .
NATURE MEDICINE, 2002, 8 (02) :136-142
[3]  
Borish Larry C., 2003, Journal of Allergy and Clinical Immunology, V111, pS460
[4]  
Brookes S T, 2001, Health Technol Assess, V5, P1
[5]   NEUROGENIC MODEL OF MIGRAINE [J].
BUZZI, MG ;
BONAMINI, M ;
MOSKOWITZ, MA .
CEPHALALGIA, 1995, 15 (04) :277-280
[6]   Primary headaches: A convergence hypothesis [J].
Cady, R ;
Schreiber, C ;
Farmer, K ;
Sheftell, F .
HEADACHE, 2002, 42 (03) :204-216
[7]   Precipitating factors of headache. A prospective study in a national control-matched survey in migraineurs and nonmigraineurs [J].
Chabriat, H ;
Danchot, J ;
Michel, P ;
Joire, JE ;
Henry, P .
HEADACHE, 1999, 39 (05) :335-338
[8]   Decreased sTNF-RI in migraine patients? [J].
Empl, M ;
Sostak, P ;
Riedel, M ;
Schwarz, M ;
Müller, N ;
Förderreuther, S ;
Straube, A .
CEPHALALGIA, 2003, 23 (01) :55-58
[9]   Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing-remitting multiple sclerosis: relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings [J].
Fainardi, E ;
Rizzo, R ;
Melchiorri, L ;
Vaghi, L ;
Castellazzi, M ;
Marzola, A ;
Govoni, V ;
Paolino, E ;
Tola, MR ;
Granieri, E ;
Baricordi, OR .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 142 (1-2) :149-158
[10]   Increased plasma transforming growth factor-β1 in migraine [J].
Ishizaki, K ;
Takeshima, T ;
Fukuhara, Y ;
Araki, H ;
Nakaso, K ;
Kusumi, M ;
Nakashima, K .
HEADACHE, 2005, 45 (09) :1224-1228
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